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Identification of Full-Length Wild-Type and Mutant Huntingtin Interacting Proteins by Crosslinking Immunoprecipitation in Mice Brain Cortex

BACKGROUND: Huntington’s disease is a neurodegenerative disorder caused by a CAG expansion in the huntingtin gene, resulting in a polyglutamine expansion in the ubiquitously expressed mutant huntingtin protein. OBJECTIVE: Here we set out to identify proteins interacting with the full-length wild-typ...

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Detalles Bibliográficos
Autores principales:	Sap, Karen A., Guler, Arzu Tugce, Bury, Aleksandra, Dekkers, Dick, Demmers, Jeroen A.A., Reits, Eric A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2021
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609692/ https://www.ncbi.nlm.nih.gov/pubmed/34151850 http://dx.doi.org/10.3233/JHD-210476

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