Cargando…

A Novel Approach to the Treatment and Prevention of Alzheimer’s Disease Based on the Pathology and Microbiology

Utilizing the pathology and microbiology found in tissue from patients with documented Alzheimer’s disease (AD), the pathogenesis of this fateful disorder has been made clear. Borrelia burgdorferi and Treponema denticola spirochetes enter the brain, mostly via neuronal pathways and the entorhinal ci...

Descripción completa

Detalles Bibliográficos
Autor principal: Allen, Herbert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609710/
https://www.ncbi.nlm.nih.gov/pubmed/34542071
http://dx.doi.org/10.3233/JAD-210429
_version_ 1784602968265326592
author Allen, Herbert B.
author_facet Allen, Herbert B.
author_sort Allen, Herbert B.
collection PubMed
description Utilizing the pathology and microbiology found in tissue from patients with documented Alzheimer’s disease (AD), the pathogenesis of this fateful disorder has been made clear. Borrelia burgdorferi and Treponema denticola spirochetes enter the brain, mostly via neuronal pathways and the entorhinal circulation. These organisms easily pass through the blood-brain barrier and have an affinity for neural tissue. Once in the brain, the spirochetes make intra- and extracellular biofilms, and it is the biofilms that create the pathology. Specifically, it is the intracellular biofilms that are ultimately responsible for neurofibrillary tangles and dendritic disintegration. The extracellular biofilms are responsible for the inflammation that initially is generated by the first responder, Toll-like receptor 2. The hypothesis that arises from this work is two-pronged: one is related to prevention; the other to treatment. Regarding prevention, it is very likely possible that AD could be prevented by periodic administration of penicillin (PCN), which would kill the spirochetes before they made biofilms; this would prevent the disease and would not allow any of the above deleterious changes generated by the biofilms to occur. As regards treatment, it may be possible to slow or prevent further decline in early AD by administration of PCN together with a biofilm disperser. The disperser would disrupt the biofilm coating and enable the PCN to kill the spirochetes. This protocol could be administered in a trial with the control arm utilizing the current treatment. The progress of the treatment could be evaluated by one of the current blood tests that is semi-quantitative. The specific protocols are listed.
format Online
Article
Text
id pubmed-8609710
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher IOS Press
record_format MEDLINE/PubMed
spelling pubmed-86097102021-12-10 A Novel Approach to the Treatment and Prevention of Alzheimer’s Disease Based on the Pathology and Microbiology Allen, Herbert B. J Alzheimers Dis Hypothesis Utilizing the pathology and microbiology found in tissue from patients with documented Alzheimer’s disease (AD), the pathogenesis of this fateful disorder has been made clear. Borrelia burgdorferi and Treponema denticola spirochetes enter the brain, mostly via neuronal pathways and the entorhinal circulation. These organisms easily pass through the blood-brain barrier and have an affinity for neural tissue. Once in the brain, the spirochetes make intra- and extracellular biofilms, and it is the biofilms that create the pathology. Specifically, it is the intracellular biofilms that are ultimately responsible for neurofibrillary tangles and dendritic disintegration. The extracellular biofilms are responsible for the inflammation that initially is generated by the first responder, Toll-like receptor 2. The hypothesis that arises from this work is two-pronged: one is related to prevention; the other to treatment. Regarding prevention, it is very likely possible that AD could be prevented by periodic administration of penicillin (PCN), which would kill the spirochetes before they made biofilms; this would prevent the disease and would not allow any of the above deleterious changes generated by the biofilms to occur. As regards treatment, it may be possible to slow or prevent further decline in early AD by administration of PCN together with a biofilm disperser. The disperser would disrupt the biofilm coating and enable the PCN to kill the spirochetes. This protocol could be administered in a trial with the control arm utilizing the current treatment. The progress of the treatment could be evaluated by one of the current blood tests that is semi-quantitative. The specific protocols are listed. IOS Press 2021-10-26 /pmc/articles/PMC8609710/ /pubmed/34542071 http://dx.doi.org/10.3233/JAD-210429 Text en © 2021 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Hypothesis
Allen, Herbert B.
A Novel Approach to the Treatment and Prevention of Alzheimer’s Disease Based on the Pathology and Microbiology
title A Novel Approach to the Treatment and Prevention of Alzheimer’s Disease Based on the Pathology and Microbiology
title_full A Novel Approach to the Treatment and Prevention of Alzheimer’s Disease Based on the Pathology and Microbiology
title_fullStr A Novel Approach to the Treatment and Prevention of Alzheimer’s Disease Based on the Pathology and Microbiology
title_full_unstemmed A Novel Approach to the Treatment and Prevention of Alzheimer’s Disease Based on the Pathology and Microbiology
title_short A Novel Approach to the Treatment and Prevention of Alzheimer’s Disease Based on the Pathology and Microbiology
title_sort novel approach to the treatment and prevention of alzheimer’s disease based on the pathology and microbiology
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609710/
https://www.ncbi.nlm.nih.gov/pubmed/34542071
http://dx.doi.org/10.3233/JAD-210429
work_keys_str_mv AT allenherbertb anovelapproachtothetreatmentandpreventionofalzheimersdiseasebasedonthepathologyandmicrobiology
AT allenherbertb novelapproachtothetreatmentandpreventionofalzheimersdiseasebasedonthepathologyandmicrobiology