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Spinoculation and retronectin highly enhance the gene transduction efficiency of Mucin-1-specific chimeric antigen receptor (CAR) in human primary T cells

BACKGROUND: Producing an appropriate number of engineered cells is considered as one of the influential factors in the successful treatments with chimeric antigen receptor (CAR) T cells. To this aim, the transduction rate of the viral vectors can play a significant role. In addition, improving trans...

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Detalles Bibliográficos
Autores principales:	Rajabzadeh, Alireza, Hamidieh, Amir Ali, Rahbarizadeh, Fatemeh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609792/ https://www.ncbi.nlm.nih.gov/pubmed/34814824 http://dx.doi.org/10.1186/s12860-021-00397-z

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