RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation

The type 1 ryanodine receptor (RyR1) is an intracellular calcium (Ca(2+)) release channel on the sarcoplasmic/endoplasmic reticulum that is required for skeletal muscle contraction. RyR1 channel activity is modulated by ligands, including the activators Ca(2+) and ATP. Patients with inherited mutati...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuan, Qi, Dridi, Haikel, Clarke, Oliver B., Reiken, Steven, Melville, Zephan, Wronska, Anetta, Kushnir, Alexander, Zalk, Ran, Sittenfeld, Leah, Marks, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609856/
https://www.ncbi.nlm.nih.gov/pubmed/34809703
http://dx.doi.org/10.1186/s40478-021-01287-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609856/
https://www.ncbi.nlm.nih.gov/pubmed/34809703
http://dx.doi.org/10.1186/s40478-021-01287-3

Ejemplares similares