Born to survive: how cancer cells resist CAR T cell therapy

Although chimeric antigen receptor T cells demonstrated remarkable efficacy in patients with chemo-resistant hematologic malignancies, a significant portion still resist or relapse. This immune evasion may be due to CAR T cells dysfunction, a hostile tumor microenvironment, or resistant cancer cells...

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Detalles Bibliográficos
Autores principales: Lemoine, Jean, Ruella, Marco, Houot, Roch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609883/
https://www.ncbi.nlm.nih.gov/pubmed/34809678
http://dx.doi.org/10.1186/s13045-021-01209-9
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author Lemoine, Jean
Ruella, Marco
Houot, Roch
author_facet Lemoine, Jean
Ruella, Marco
Houot, Roch
author_sort Lemoine, Jean
collection PubMed
description Although chimeric antigen receptor T cells demonstrated remarkable efficacy in patients with chemo-resistant hematologic malignancies, a significant portion still resist or relapse. This immune evasion may be due to CAR T cells dysfunction, a hostile tumor microenvironment, or resistant cancer cells. Here, we review the intrinsic resistance mechanisms of cancer cells to CAR T cell therapy and potential strategies to circumvent them.
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spelling pubmed-86098832021-11-29 Born to survive: how cancer cells resist CAR T cell therapy Lemoine, Jean Ruella, Marco Houot, Roch J Hematol Oncol Review Although chimeric antigen receptor T cells demonstrated remarkable efficacy in patients with chemo-resistant hematologic malignancies, a significant portion still resist or relapse. This immune evasion may be due to CAR T cells dysfunction, a hostile tumor microenvironment, or resistant cancer cells. Here, we review the intrinsic resistance mechanisms of cancer cells to CAR T cell therapy and potential strategies to circumvent them. BioMed Central 2021-11-22 /pmc/articles/PMC8609883/ /pubmed/34809678 http://dx.doi.org/10.1186/s13045-021-01209-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Lemoine, Jean
Ruella, Marco
Houot, Roch
Born to survive: how cancer cells resist CAR T cell therapy
title Born to survive: how cancer cells resist CAR T cell therapy
title_full Born to survive: how cancer cells resist CAR T cell therapy
title_fullStr Born to survive: how cancer cells resist CAR T cell therapy
title_full_unstemmed Born to survive: how cancer cells resist CAR T cell therapy
title_short Born to survive: how cancer cells resist CAR T cell therapy
title_sort born to survive: how cancer cells resist car t cell therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609883/
https://www.ncbi.nlm.nih.gov/pubmed/34809678
http://dx.doi.org/10.1186/s13045-021-01209-9
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