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Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma
Cutaneous squamous cell carcinomas (cSCC) represent one of the most diagnosed non-melanoma skin cancers and its incidence is increasing globally. Whereas early stage and low risk cSCC is typically treated with surgery, and in some cases other localized therapeutic modalities, locally advanced or met...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609954/ https://www.ncbi.nlm.nih.gov/pubmed/34877077 http://dx.doi.org/10.5826/dpc.11S2a169S |
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author | Aboul-Fettouh, Nader Morse, Daniel Patel, Jigar Migden, Michael R. |
author_facet | Aboul-Fettouh, Nader Morse, Daniel Patel, Jigar Migden, Michael R. |
author_sort | Aboul-Fettouh, Nader |
collection | PubMed |
description | Cutaneous squamous cell carcinomas (cSCC) represent one of the most diagnosed non-melanoma skin cancers and its incidence is increasing globally. Whereas early stage and low risk cSCC is typically treated with surgery, and in some cases other localized therapeutic modalities, locally advanced or metastatic cSCC is a cause of significant morbidity and mortality that requires a different approach to therapy. Therapeutic attempts at treating advanced cSCC include a multi-disciplinary approach with considerations for surgery, radiation, and systemic therapies. In this review, we will discuss the various systemic therapies that have been trialed for advanced cSCC, beginning with the early cytotoxic and platinum-based agents as well as their corresponding limitations. We will then review the targeted approaches using EGFR inhibitors prior to discussing the more recent immunotherapeutics that have shown good tumor responses in this often-lethal disease. |
format | Online Article Text |
id | pubmed-8609954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Mattioli 1885 |
record_format | MEDLINE/PubMed |
spelling | pubmed-86099542021-12-06 Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma Aboul-Fettouh, Nader Morse, Daniel Patel, Jigar Migden, Michael R. Dermatol Pract Concept Review Cutaneous squamous cell carcinomas (cSCC) represent one of the most diagnosed non-melanoma skin cancers and its incidence is increasing globally. Whereas early stage and low risk cSCC is typically treated with surgery, and in some cases other localized therapeutic modalities, locally advanced or metastatic cSCC is a cause of significant morbidity and mortality that requires a different approach to therapy. Therapeutic attempts at treating advanced cSCC include a multi-disciplinary approach with considerations for surgery, radiation, and systemic therapies. In this review, we will discuss the various systemic therapies that have been trialed for advanced cSCC, beginning with the early cytotoxic and platinum-based agents as well as their corresponding limitations. We will then review the targeted approaches using EGFR inhibitors prior to discussing the more recent immunotherapeutics that have shown good tumor responses in this often-lethal disease. Mattioli 1885 2021-10-01 /pmc/articles/PMC8609954/ /pubmed/34877077 http://dx.doi.org/10.5826/dpc.11S2a169S Text en ©2021 Aboul-Fettouh et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License BY-NC-4.0, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. |
spellingShingle | Review Aboul-Fettouh, Nader Morse, Daniel Patel, Jigar Migden, Michael R. Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma |
title | Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma |
title_full | Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma |
title_fullStr | Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma |
title_full_unstemmed | Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma |
title_short | Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma |
title_sort | immunotherapy and systemic treatment of cutaneous squamous cell carcinoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609954/ https://www.ncbi.nlm.nih.gov/pubmed/34877077 http://dx.doi.org/10.5826/dpc.11S2a169S |
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