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Iron overload during the treatment of acute leukemia: pretransplant transfusion experience

BACKGROUND: Recent studies have shown the increased risk of mortality in cases with acute leukemia and iron overload. We aimed to determine the status of iron overload in patients with acute leukemia. MATERIALS & METHODS: Patients diagnosed with acute lymphoblastic leukemia (ALL) and acute myelo...

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Autores principales: Yokus, Osman, Herek, Celalettin, Cinli, Tahir Alper, Goze, Hasan, Serin, Istemi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609998/
https://www.ncbi.nlm.nih.gov/pubmed/34840721
http://dx.doi.org/10.2217/ijh-2021-0005
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author Yokus, Osman
Herek, Celalettin
Cinli, Tahir Alper
Goze, Hasan
Serin, Istemi
author_facet Yokus, Osman
Herek, Celalettin
Cinli, Tahir Alper
Goze, Hasan
Serin, Istemi
author_sort Yokus, Osman
collection PubMed
description BACKGROUND: Recent studies have shown the increased risk of mortality in cases with acute leukemia and iron overload. We aimed to determine the status of iron overload in patients with acute leukemia. MATERIALS & METHODS: Patients diagnosed with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) between January 2015 and December 2019 were included in the study. RESULTS: At 6 months, there were statistically more patients with serum ferritin >1000 in the AML group compared to the ALL group (p = 0,011). CONCLUSION: Iron overload occurs earlier in patients with AML; the difference disappears after 6 months of treatment. It is the correct point to emphasize that iron overload is an important factor of pretransplant morbidity, especially in AML cases.
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spelling pubmed-86099982021-11-26 Iron overload during the treatment of acute leukemia: pretransplant transfusion experience Yokus, Osman Herek, Celalettin Cinli, Tahir Alper Goze, Hasan Serin, Istemi Int J Hematol Oncol Research Article BACKGROUND: Recent studies have shown the increased risk of mortality in cases with acute leukemia and iron overload. We aimed to determine the status of iron overload in patients with acute leukemia. MATERIALS & METHODS: Patients diagnosed with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) between January 2015 and December 2019 were included in the study. RESULTS: At 6 months, there were statistically more patients with serum ferritin >1000 in the AML group compared to the ALL group (p = 0,011). CONCLUSION: Iron overload occurs earlier in patients with AML; the difference disappears after 6 months of treatment. It is the correct point to emphasize that iron overload is an important factor of pretransplant morbidity, especially in AML cases. Future Medicine Ltd 2021-11-12 /pmc/articles/PMC8609998/ /pubmed/34840721 http://dx.doi.org/10.2217/ijh-2021-0005 Text en © 2021 Future Medicine Ltd https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Research Article
Yokus, Osman
Herek, Celalettin
Cinli, Tahir Alper
Goze, Hasan
Serin, Istemi
Iron overload during the treatment of acute leukemia: pretransplant transfusion experience
title Iron overload during the treatment of acute leukemia: pretransplant transfusion experience
title_full Iron overload during the treatment of acute leukemia: pretransplant transfusion experience
title_fullStr Iron overload during the treatment of acute leukemia: pretransplant transfusion experience
title_full_unstemmed Iron overload during the treatment of acute leukemia: pretransplant transfusion experience
title_short Iron overload during the treatment of acute leukemia: pretransplant transfusion experience
title_sort iron overload during the treatment of acute leukemia: pretransplant transfusion experience
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609998/
https://www.ncbi.nlm.nih.gov/pubmed/34840721
http://dx.doi.org/10.2217/ijh-2021-0005
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