Cargando…

New tale on LianHuaQingWen: IL6R/IL6/IL6ST complex is a potential target for COVID-19 treatment

LianHuaQingWen (LHQW) improves clinical symptoms and alleviates the severity of COVID-19, but the mechanism is unclear. This study aimed to investigate the potential molecular targets and mechanisms of LHQW in treating COVID-19 using a network pharmacology-based approach and molecular docking analys...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tianyu, Zhao, Xiaoli, Cui, Yaru, Wang, Min, Zhang, Fengli, Yue, Kan, He, Li, Chen, Jing, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610116/ https://www.ncbi.nlm.nih.gov/pubmed/34731090 http://dx.doi.org/10.18632/aging.203666

Ejemplares similares

Broad Anti-Viral Capacities of Lian-Hua-Qing-Wen Capsule and Jin-Hua-Qing-Gan Granule and Rational use Against COVID-19 Based on Literature Mining
por: Shi, Mingfei, et al.
Publicado: (2021)

Efficacy and safety of Lian-Hua Qing-Wen granule for COVID-2019: A protocol for systematic review and meta-analysis
por: Hu, Zhipeng, et al.
Publicado: (2020)

Lian Hua Qing Wen Capsules, a Potent Epithelial Protector in Acute Lung Injury Model, Block Proapoptotic Communication Between Macrophages, and Alveolar Epithelial Cells
por: Li, Qi, et al.
Publicado: (2020)

Network pharmacology analysis of the therapeutic mechanisms of the traditional Chinese herbal formula Lian Hua Qing Wen in Corona virus disease 2019 (COVID-19), gives fundamental support to the clinical use of LHQW
por: Zheng, Shichao, et al.
Publicado: (2020)

Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population
por: Rodrigues, Fabíola Brasil Barbosa, et al.
Publicado: (2023)

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6
por: Rose-John, Stefan
Publicado: (2012)

A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia
por: Huusko, Johanna M, et al.
Publicado: (2014)

IL6/IL6R genetic diversity and plasma IL6 levels in bipolar disorder: An Indo-French study
por: Sundaresh, Aparna, et al.
Publicado: (2019)

IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm
por: Kamińska, Joanna, et al.
Publicado: (2021)

Dissecting the IL‐6 pathway in cardiometabolic disease: A Mendelian randomization study on both IL6 and IL6R
por: Cupido, Arjen J., et al.
Publicado: (2022)

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL- 6 and prolongation of the plasma half-life of IL-6
Publicado: (1996)

Pathogenic roles of IL-6 and IL-6 blocking therapy on rheumatoid arthritis
por: Yoshizaki, K, et al.
Publicado: (2003)

Higher IL-6 and IL6:IGF Ratio in Patients with Barth Syndrome
por: Wilson, Lori D, et al.
Publicado: (2012)

Expression and significance of IL-6 and IL-8 in canine mammary gland tumors
por: Ren, Xiaoli, et al.
Publicado: (2023)

Assessment of Interleukins IL-4, IL-6, IL-8, IL-10 in Acute Urticaria
por: Papadopoulos, Jordan, et al.
Publicado: (2014)

The IL6 Gene Promoter SNP and Plasma IL-6 in Response to Diet Intervention
por: Rana, Brinda K., et al.
Publicado: (2017)

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse
por: Schwerd, Tobias, et al.
Publicado: (2020)

Special issue on Interleukin-6 (IL-6)
por: Rincon, Mercedes
Publicado: (2012)

Inhibition of IL-6+IL-6 soluble receptor-stimulated aromatase activity by the IL-6 antagonist, Sant 7, in breast tissue-derived fibroblasts
por: Purohit, A, et al.
Publicado: (2003)

Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro
por: Flynn, Charlotte M., et al.
Publicado: (2020)

The nature of human IL-6
por: Puel, Anne, et al.
Publicado: (2019)

IL-1beta, IL-6 and IL-8 levels in gyneco-obstetric infections.
por: Basso, Beatriz, et al.
Publicado: (2005)

Circulating IL-6, IL-10, and TNF-alpha and IL-10/IL-6 and IL-10/TNF-alpha ratio profiles of polyparasitized individuals in rural and urban areas of gabon
por: M’Bondoukwé, Noé Patrick, et al.
Publicado: (2022)

IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis
por: Wang, Jianmei, et al.
Publicado: (2013)

A Potential Role of IL-6/IL-6R in the Development and Management of Colon Cancer
por: Turano, Mimmo, et al.
Publicado: (2021)

Targeting IL-6 Trans-Signaling: Amplifying the Benefits of IL-6 Inhibition in Myocardial Infarction
por: Aukrust, Pål, et al.
Publicado: (2021)

Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα/gp130 hexameric signaling complex formation
por: Chou, Chun-Chi, et al.
Publicado: (2022)

Interleukin‐6 signaling requires only few IL‐6 molecules: Relation to physiological concentrations of extracellular IL‐6
por: Hansen, Morten B.
Publicado: (2020)

Serum IL-1β, IL-2, and IL-6 in Insulin-Dependent Diabetic Children
por: Dogan, Yasar, et al.
Publicado: (2006)

Effects of IL-1β, IL-6 and IL-8 on erythrocytes, platelets and clot viscoelasticity
por: Bester, Janette, et al.
Publicado: (2016)

Serum levels of IL-6, IL-8, and IL-10 are indicators of prognosis in pancreatic cancer
por: Feng, Lanyun, et al.
Publicado: (2018)

Athletic humans and horses: Comparative analysis of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) expression in peripheral blood mononuclear cells in trained and untrained subjects at rest
por: Capomaccio, Stefano, et al.
Publicado: (2011)

Association Between Serum IL-6, IL-10, IL-12, and IL-23 Levels and Severity of Liver Cirrhosis
por: Rey, Imelda, et al.
Publicado: (2021)

Expression analysis of cytokines IL-5, IL-6, IL-8, IL-17 and VEGF in breast cancer patients
por: Liu, Gang, et al.
Publicado: (2022)

Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies
por: Tawara, Ken, et al.
Publicado: (2011)

Classical Signaling and Trans-Signaling Pathways Stimulated by Megalobrama amblycephala IL-6 and IL-6R
por: Wang, Jixiu, et al.
Publicado: (2022)

Genetic IL-6R variants and therapeutic inhibition of IL-6 receptor signalling in COVID-19
por: Garbers, Christoph, et al.
Publicado: (2021)

IL-1β, IL-6, and RANTES as Biomarkers of Chikungunya Severity
por: Ng, Lisa F. P., et al.
Publicado: (2009)

IL6 and IL10 are genetic susceptibility factors of periodontal disease
por: Scapoli, Luca, et al.
Publicado: (2012)

Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling
por: Luan, Danny, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_srrfukjmo7vfchqrugo6431l1d