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UBB(+1) reduces amyloid-β cytotoxicity by activation of autophagy in yeast
UBB(+1) is a mutated version of ubiquitin B peptide caused by a transcriptional frameshift due to the RNA polymerase II “slippage”. The accumulation of UBB(+1) has been linked to ubiquitin-proteasome system (UPS) dysfunction and neurodegeneration. Alzheimer’s disease (AD) is defined as a progressive...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Impact Journals
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610117/ https://www.ncbi.nlm.nih.gov/pubmed/34751669 http://dx.doi.org/10.18632/aging.203681 |