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The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma

OBJECTIVE: Patients with non–small cell lung cancer (NSCLC) respond differently to cytokine-induced killer cell (CIK) treatment. Therefore, potential prognostic markers to identify patients who would benefit from CIK treatment must be elucidated. The current research aimed at identifying predictive...

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Autores principales: Wang, Jian, Yang, Fan, Sun, Qian, Zeng, Ziqing, Liu, Min, Yu, Wenwen, Zhang, Peng, Yu, Jinpu, Yang, Lili, Zhang, Xinwei, Ren, Xiubao, Wei, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Compuscript 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610154/
https://www.ncbi.nlm.nih.gov/pubmed/34459571
http://dx.doi.org/10.20892/j.issn.2095-3941.2021.0023
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author Wang, Jian
Yang, Fan
Sun, Qian
Zeng, Ziqing
Liu, Min
Yu, Wenwen
Zhang, Peng
Yu, Jinpu
Yang, Lili
Zhang, Xinwei
Ren, Xiubao
Wei, Feng
author_facet Wang, Jian
Yang, Fan
Sun, Qian
Zeng, Ziqing
Liu, Min
Yu, Wenwen
Zhang, Peng
Yu, Jinpu
Yang, Lili
Zhang, Xinwei
Ren, Xiubao
Wei, Feng
author_sort Wang, Jian
collection PubMed
description OBJECTIVE: Patients with non–small cell lung cancer (NSCLC) respond differently to cytokine-induced killer cell (CIK) treatment. Therefore, potential prognostic markers to identify patients who would benefit from CIK treatment must be elucidated. The current research aimed at identifying predictive prognostic markers for efficient CIK treatment of patients with NSCLC. METHODS: Patients histologically diagnosed with NSCLC were enrolled from the Tianjin Medical University Cancer Institute and Hospital. We performed whole-exome sequencing (WES) on the tumor tissues and paired adjacent benign tissues collected from 50 patients with NSCLC, and RNA-seq on tumor tissues of 17 patients with NSCLC before CIK immunotherapy treatment. Multivariate Cox proportional hazard regression analysis was used to analyze the association between clinical parameters and prognostic relevance. WES and RNA-seq data between lung squamous cell carcinoma (SCC) and adenocarcinoma (Aden) were analyzed and compared. RESULTS: The pathology subtype of lung cancer was the most significantly relevant clinical parameter associated with DFS, as analyzed by multivariate Cox proportional hazard regression (P = 0.031). The patients with lung SCC showed better CIK treatment efficacy and extended DFS after CIK treatment. Relatively low expression of HLA class II genes and checkpoint molecules, and less immunosuppressive immune cell infiltration were identified in the patients with lung SCC. CONCLUSIONS: Coordinated suppression of the expression of HLA class II genes and checkpoint molecules, as well as less immune suppressive cell infiltration together contributed to the better CIK treatment efficacy in lung SCC than lung Aden.
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spelling pubmed-86101542021-12-09 The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma Wang, Jian Yang, Fan Sun, Qian Zeng, Ziqing Liu, Min Yu, Wenwen Zhang, Peng Yu, Jinpu Yang, Lili Zhang, Xinwei Ren, Xiubao Wei, Feng Cancer Biol Med Original Article OBJECTIVE: Patients with non–small cell lung cancer (NSCLC) respond differently to cytokine-induced killer cell (CIK) treatment. Therefore, potential prognostic markers to identify patients who would benefit from CIK treatment must be elucidated. The current research aimed at identifying predictive prognostic markers for efficient CIK treatment of patients with NSCLC. METHODS: Patients histologically diagnosed with NSCLC were enrolled from the Tianjin Medical University Cancer Institute and Hospital. We performed whole-exome sequencing (WES) on the tumor tissues and paired adjacent benign tissues collected from 50 patients with NSCLC, and RNA-seq on tumor tissues of 17 patients with NSCLC before CIK immunotherapy treatment. Multivariate Cox proportional hazard regression analysis was used to analyze the association between clinical parameters and prognostic relevance. WES and RNA-seq data between lung squamous cell carcinoma (SCC) and adenocarcinoma (Aden) were analyzed and compared. RESULTS: The pathology subtype of lung cancer was the most significantly relevant clinical parameter associated with DFS, as analyzed by multivariate Cox proportional hazard regression (P = 0.031). The patients with lung SCC showed better CIK treatment efficacy and extended DFS after CIK treatment. Relatively low expression of HLA class II genes and checkpoint molecules, and less immunosuppressive immune cell infiltration were identified in the patients with lung SCC. CONCLUSIONS: Coordinated suppression of the expression of HLA class II genes and checkpoint molecules, as well as less immune suppressive cell infiltration together contributed to the better CIK treatment efficacy in lung SCC than lung Aden. Compuscript 2021-11-15 2021-08-30 /pmc/articles/PMC8610154/ /pubmed/34459571 http://dx.doi.org/10.20892/j.issn.2095-3941.2021.0023 Text en Copyright: © 2021, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0 (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Wang, Jian
Yang, Fan
Sun, Qian
Zeng, Ziqing
Liu, Min
Yu, Wenwen
Zhang, Peng
Yu, Jinpu
Yang, Lili
Zhang, Xinwei
Ren, Xiubao
Wei, Feng
The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma
title The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma
title_full The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma
title_fullStr The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma
title_full_unstemmed The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma
title_short The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma
title_sort prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610154/
https://www.ncbi.nlm.nih.gov/pubmed/34459571
http://dx.doi.org/10.20892/j.issn.2095-3941.2021.0023
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