Cargando…

Antibiotic resistance in agriculture: Perspectives on upcoming strategies to overcome upsurge in resistance

Antibiotic resistance is a massive problem rising constantly and spreading rapidly since the past decade. The major underlying mechanism responsible for this problem is an overuse or severe misuse of antibiotics. Regardless of this emerging global threat, antibiotics are still being widely used, not...

Descripción completa

Detalles Bibliográficos
Autores principales: Mann, Avantika, Nehra, Kiran, Rana, J.S., Dahiya, Twinkle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610298/
https://www.ncbi.nlm.nih.gov/pubmed/34841321
http://dx.doi.org/10.1016/j.crmicr.2021.100030
_version_ 1784603083509071872
author Mann, Avantika
Nehra, Kiran
Rana, J.S.
Dahiya, Twinkle
author_facet Mann, Avantika
Nehra, Kiran
Rana, J.S.
Dahiya, Twinkle
author_sort Mann, Avantika
collection PubMed
description Antibiotic resistance is a massive problem rising constantly and spreading rapidly since the past decade. The major underlying mechanism responsible for this problem is an overuse or severe misuse of antibiotics. Regardless of this emerging global threat, antibiotics are still being widely used, not only for treatment of human infections, but also to a great extent in agriculture, livestock and animal husbandry. If the current scenario persists, we might enter into a post-antibiotic era where drugs might not be able to treat even the simplest of infections. This review discusses the current status of antibiotic utilization and molecular basis of antibiotic resistance mechanisms acquired by bacteria, along with the modes of transmittance of the resultant resistant genes into human pathogens through their cycling among different ecosystems. The main focus of the article is to provide an insight into the different molecular and other strategies currently being studied worldwide for their use as an alternate to antibiotics with an overall aim to overcome or minimize the global problem of antibiotic resistance.
format Online
Article
Text
id pubmed-8610298
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-86102982021-11-26 Antibiotic resistance in agriculture: Perspectives on upcoming strategies to overcome upsurge in resistance Mann, Avantika Nehra, Kiran Rana, J.S. Dahiya, Twinkle Curr Res Microb Sci Review Article Antibiotic resistance is a massive problem rising constantly and spreading rapidly since the past decade. The major underlying mechanism responsible for this problem is an overuse or severe misuse of antibiotics. Regardless of this emerging global threat, antibiotics are still being widely used, not only for treatment of human infections, but also to a great extent in agriculture, livestock and animal husbandry. If the current scenario persists, we might enter into a post-antibiotic era where drugs might not be able to treat even the simplest of infections. This review discusses the current status of antibiotic utilization and molecular basis of antibiotic resistance mechanisms acquired by bacteria, along with the modes of transmittance of the resultant resistant genes into human pathogens through their cycling among different ecosystems. The main focus of the article is to provide an insight into the different molecular and other strategies currently being studied worldwide for their use as an alternate to antibiotics with an overall aim to overcome or minimize the global problem of antibiotic resistance. Elsevier 2021-04-02 /pmc/articles/PMC8610298/ /pubmed/34841321 http://dx.doi.org/10.1016/j.crmicr.2021.100030 Text en © 2021 The Author(s). Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Mann, Avantika
Nehra, Kiran
Rana, J.S.
Dahiya, Twinkle
Antibiotic resistance in agriculture: Perspectives on upcoming strategies to overcome upsurge in resistance
title Antibiotic resistance in agriculture: Perspectives on upcoming strategies to overcome upsurge in resistance
title_full Antibiotic resistance in agriculture: Perspectives on upcoming strategies to overcome upsurge in resistance
title_fullStr Antibiotic resistance in agriculture: Perspectives on upcoming strategies to overcome upsurge in resistance
title_full_unstemmed Antibiotic resistance in agriculture: Perspectives on upcoming strategies to overcome upsurge in resistance
title_short Antibiotic resistance in agriculture: Perspectives on upcoming strategies to overcome upsurge in resistance
title_sort antibiotic resistance in agriculture: perspectives on upcoming strategies to overcome upsurge in resistance
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610298/
https://www.ncbi.nlm.nih.gov/pubmed/34841321
http://dx.doi.org/10.1016/j.crmicr.2021.100030
work_keys_str_mv AT mannavantika antibioticresistanceinagricultureperspectivesonupcomingstrategiestoovercomeupsurgeinresistance
AT nehrakiran antibioticresistanceinagricultureperspectivesonupcomingstrategiestoovercomeupsurgeinresistance
AT ranajs antibioticresistanceinagricultureperspectivesonupcomingstrategiestoovercomeupsurgeinresistance
AT dahiyatwinkle antibioticresistanceinagricultureperspectivesonupcomingstrategiestoovercomeupsurgeinresistance