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The bacteriophage decides own tracks: When they are with or against the bacteria
Bacteriophages, bacteria-infecting viruses, are considered by many researchers a promising solution for antimicrobial resistance. On the other hand, some phages have shown contribution to bacterial resistance phenomenon by transducing antimicrobial resistance genes to their bacterial hosts. Contradi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610337/ https://www.ncbi.nlm.nih.gov/pubmed/34841341 http://dx.doi.org/10.1016/j.crmicr.2021.100050 |
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author | Makky, Salsabil Dawoud, Alyaa Safwat, Anan Abdelsattar, Abdallah S. Rezk, Nouran El-Shibiny, Ayman |
author_facet | Makky, Salsabil Dawoud, Alyaa Safwat, Anan Abdelsattar, Abdallah S. Rezk, Nouran El-Shibiny, Ayman |
author_sort | Makky, Salsabil |
collection | PubMed |
description | Bacteriophages, bacteria-infecting viruses, are considered by many researchers a promising solution for antimicrobial resistance. On the other hand, some phages have shown contribution to bacterial resistance phenomenon by transducing antimicrobial resistance genes to their bacterial hosts. Contradictory consequences of infections are correlated to different phage lifecycles. Out of four known lifecycles, lysogenic and lytic pathways have been riddles since the uncontrolled conversion between them could negatively affect the intended use of phages. However, phages still can be engineered for applications against bacterial and viral infections to ensure high efficiency. This review highlights two main aspects: (1) the different lifecycles as well as the different factors that affect lytic-lysogenic switch are discussed, including the intracellular and molecular factors control this decision. In addition, different models which describe the effect of phages on the ecosystem are compared, besides the approaches to study the switch. (2) An overview on the contribution of the phage in the evolution of the bacteria, instead of eating them, as a consequence of different mode of actions. As well, how phage display has helped in restricting phage cheating and how it could open new gates for immunization and pandemics control will be tacked. |
format | Online Article Text |
id | pubmed-8610337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-86103372021-11-26 The bacteriophage decides own tracks: When they are with or against the bacteria Makky, Salsabil Dawoud, Alyaa Safwat, Anan Abdelsattar, Abdallah S. Rezk, Nouran El-Shibiny, Ayman Curr Res Microb Sci Review Article Bacteriophages, bacteria-infecting viruses, are considered by many researchers a promising solution for antimicrobial resistance. On the other hand, some phages have shown contribution to bacterial resistance phenomenon by transducing antimicrobial resistance genes to their bacterial hosts. Contradictory consequences of infections are correlated to different phage lifecycles. Out of four known lifecycles, lysogenic and lytic pathways have been riddles since the uncontrolled conversion between them could negatively affect the intended use of phages. However, phages still can be engineered for applications against bacterial and viral infections to ensure high efficiency. This review highlights two main aspects: (1) the different lifecycles as well as the different factors that affect lytic-lysogenic switch are discussed, including the intracellular and molecular factors control this decision. In addition, different models which describe the effect of phages on the ecosystem are compared, besides the approaches to study the switch. (2) An overview on the contribution of the phage in the evolution of the bacteria, instead of eating them, as a consequence of different mode of actions. As well, how phage display has helped in restricting phage cheating and how it could open new gates for immunization and pandemics control will be tacked. Elsevier 2021-07-31 /pmc/articles/PMC8610337/ /pubmed/34841341 http://dx.doi.org/10.1016/j.crmicr.2021.100050 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Makky, Salsabil Dawoud, Alyaa Safwat, Anan Abdelsattar, Abdallah S. Rezk, Nouran El-Shibiny, Ayman The bacteriophage decides own tracks: When they are with or against the bacteria |
title | The bacteriophage decides own tracks: When they are with or against the bacteria |
title_full | The bacteriophage decides own tracks: When they are with or against the bacteria |
title_fullStr | The bacteriophage decides own tracks: When they are with or against the bacteria |
title_full_unstemmed | The bacteriophage decides own tracks: When they are with or against the bacteria |
title_short | The bacteriophage decides own tracks: When they are with or against the bacteria |
title_sort | bacteriophage decides own tracks: when they are with or against the bacteria |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610337/ https://www.ncbi.nlm.nih.gov/pubmed/34841341 http://dx.doi.org/10.1016/j.crmicr.2021.100050 |
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