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The role played by bacterial infections in the onset and metastasis of cancer

Understanding various responses of cells towards change in their external environment, presence of other species and is important in identifying and correlating the mechanisms leading to malignant transformations and cancer development. Although uncovering and comprehending the association between b...

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Detalles Bibliográficos
Autores principales: Khatun, Sajmina, Appidi, Tejaswini, Rengan, Aravind Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610348/
https://www.ncbi.nlm.nih.gov/pubmed/34841367
http://dx.doi.org/10.1016/j.crmicr.2021.100078
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author Khatun, Sajmina
Appidi, Tejaswini
Rengan, Aravind Kumar
author_facet Khatun, Sajmina
Appidi, Tejaswini
Rengan, Aravind Kumar
author_sort Khatun, Sajmina
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description Understanding various responses of cells towards change in their external environment, presence of other species and is important in identifying and correlating the mechanisms leading to malignant transformations and cancer development. Although uncovering and comprehending the association between bacteria and cancer is highly challenging, it promises excellent perspectives and approaches for successful cancer therapy. This review introduces various bacterial species, their virulence factors, and their role in cell transformations leading to cancer (particularly gastric, oral, colon, and breast cancer). Bacterial dysbiosis permutates host cells, causes inflammation, and results in tumorigenesis. This review explored bacterial-mediated host cell transformation causing chronic inflammation, immune receptor hyperactivation/absconding immune recognition, and genomic instability. Bacterial infections downregulate E-cadherin, leading to loosening of epithelial tight junction polarity and triggers metastasis. In addition to understanding the role of bacterial infections in cancer development, we have also reviewed the application of bacteria for cancer therapy. The emergence of bacteriotherapy combined with conventional therapies led to new and effective ways of overcoming challenges associated with available treatments. This review discusses the application of bacterial minicells, microswimmers, and outer cell membrane vesicles (OMV) for drug delivery applications.
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spelling pubmed-86103482021-11-26 The role played by bacterial infections in the onset and metastasis of cancer Khatun, Sajmina Appidi, Tejaswini Rengan, Aravind Kumar Curr Res Microb Sci Review Article Understanding various responses of cells towards change in their external environment, presence of other species and is important in identifying and correlating the mechanisms leading to malignant transformations and cancer development. Although uncovering and comprehending the association between bacteria and cancer is highly challenging, it promises excellent perspectives and approaches for successful cancer therapy. This review introduces various bacterial species, their virulence factors, and their role in cell transformations leading to cancer (particularly gastric, oral, colon, and breast cancer). Bacterial dysbiosis permutates host cells, causes inflammation, and results in tumorigenesis. This review explored bacterial-mediated host cell transformation causing chronic inflammation, immune receptor hyperactivation/absconding immune recognition, and genomic instability. Bacterial infections downregulate E-cadherin, leading to loosening of epithelial tight junction polarity and triggers metastasis. In addition to understanding the role of bacterial infections in cancer development, we have also reviewed the application of bacteria for cancer therapy. The emergence of bacteriotherapy combined with conventional therapies led to new and effective ways of overcoming challenges associated with available treatments. This review discusses the application of bacterial minicells, microswimmers, and outer cell membrane vesicles (OMV) for drug delivery applications. Elsevier 2021-10-26 /pmc/articles/PMC8610348/ /pubmed/34841367 http://dx.doi.org/10.1016/j.crmicr.2021.100078 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Khatun, Sajmina
Appidi, Tejaswini
Rengan, Aravind Kumar
The role played by bacterial infections in the onset and metastasis of cancer
title The role played by bacterial infections in the onset and metastasis of cancer
title_full The role played by bacterial infections in the onset and metastasis of cancer
title_fullStr The role played by bacterial infections in the onset and metastasis of cancer
title_full_unstemmed The role played by bacterial infections in the onset and metastasis of cancer
title_short The role played by bacterial infections in the onset and metastasis of cancer
title_sort role played by bacterial infections in the onset and metastasis of cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610348/
https://www.ncbi.nlm.nih.gov/pubmed/34841367
http://dx.doi.org/10.1016/j.crmicr.2021.100078
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