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Mathematical modelling of COVID-19 transmission dynamics in a partially comorbid community

A deterministic [Formula: see text] epidemic model that describes the spreading of SARS-COV-2 within a community with comorbidities is formulated. Size dependent area is incorporated into the model to quantify the effect of social distancing and the results indicate that the risk of community transm...

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Autores principales: Ssebuliba, J., Nakakawa, J.N., Ssematimba, A., Mugisha, J.Y.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610571/
http://dx.doi.org/10.1016/j.padiff.2021.100212
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author Ssebuliba, J.
Nakakawa, J.N.
Ssematimba, A.
Mugisha, J.Y.T.
author_facet Ssebuliba, J.
Nakakawa, J.N.
Ssematimba, A.
Mugisha, J.Y.T.
author_sort Ssebuliba, J.
collection PubMed
description A deterministic [Formula: see text] epidemic model that describes the spreading of SARS-COV-2 within a community with comorbidities is formulated. Size dependent area is incorporated into the model to quantify the effect of social distancing and the results indicate that the risk of community transmission is optimally minimised when the occupancy area is increased. The reproduction number is shown to have a positive relationship with the infection rate, the proportion of individuals with comorbidities and the proportion of susceptible individuals adhering to standard operating procedures. The model exhibits a unique endemic equilibrium whose stability largely depends on the rate of hospitalisation of individuals with underlying health conditions ([Formula: see text]) as compared to those without these conditions ([Formula: see text]), such that stability is guaranteed if [Formula: see text]. Furthermore, if individuals with comorbidities effectively report for treatment and hospitalisation at a rate of 0.5 per day, the epidemic curve peaks 3-fold higher among people with comorbidities. The infection peaks are delayed if the area occupied by community is increased. In conclusion, we observed that community infections increase significantly with decreasing detection rates for both individuals with or without comorbidities.
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spelling pubmed-86105712021-11-24 Mathematical modelling of COVID-19 transmission dynamics in a partially comorbid community Ssebuliba, J. Nakakawa, J.N. Ssematimba, A. Mugisha, J.Y.T. Partial Differential Equations in Applied Mathematics Article A deterministic [Formula: see text] epidemic model that describes the spreading of SARS-COV-2 within a community with comorbidities is formulated. Size dependent area is incorporated into the model to quantify the effect of social distancing and the results indicate that the risk of community transmission is optimally minimised when the occupancy area is increased. The reproduction number is shown to have a positive relationship with the infection rate, the proportion of individuals with comorbidities and the proportion of susceptible individuals adhering to standard operating procedures. The model exhibits a unique endemic equilibrium whose stability largely depends on the rate of hospitalisation of individuals with underlying health conditions ([Formula: see text]) as compared to those without these conditions ([Formula: see text]), such that stability is guaranteed if [Formula: see text]. Furthermore, if individuals with comorbidities effectively report for treatment and hospitalisation at a rate of 0.5 per day, the epidemic curve peaks 3-fold higher among people with comorbidities. The infection peaks are delayed if the area occupied by community is increased. In conclusion, we observed that community infections increase significantly with decreasing detection rates for both individuals with or without comorbidities. The Authors. Published by Elsevier B.V. 2022-06 2021-11-24 /pmc/articles/PMC8610571/ http://dx.doi.org/10.1016/j.padiff.2021.100212 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ssebuliba, J.
Nakakawa, J.N.
Ssematimba, A.
Mugisha, J.Y.T.
Mathematical modelling of COVID-19 transmission dynamics in a partially comorbid community
title Mathematical modelling of COVID-19 transmission dynamics in a partially comorbid community
title_full Mathematical modelling of COVID-19 transmission dynamics in a partially comorbid community
title_fullStr Mathematical modelling of COVID-19 transmission dynamics in a partially comorbid community
title_full_unstemmed Mathematical modelling of COVID-19 transmission dynamics in a partially comorbid community
title_short Mathematical modelling of COVID-19 transmission dynamics in a partially comorbid community
title_sort mathematical modelling of covid-19 transmission dynamics in a partially comorbid community
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610571/
http://dx.doi.org/10.1016/j.padiff.2021.100212
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