Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways

BACKGROUND: Carnosic acid (CA) is a polyphenolic diterpene extracted from rosemary. Reports have shown that CA possesses anticancer activity. However, whether CA inhibits esophageal squamous cell carcinoma, an aggressive type of esophageal cancer, remains untested. METHODS: The effects of CA on cell...

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Detalles Bibliográficos
Autores principales: Jiang, Sicong, Qiu, Yinda, Wang, Zhaozhen, Ji, Yulong, Zhang, Xiaofang, Yan, Xiaosong, Zhan, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610725/
https://www.ncbi.nlm.nih.gov/pubmed/34824582
http://dx.doi.org/10.1155/2021/4451533
Descripción
Sumario:BACKGROUND: Carnosic acid (CA) is a polyphenolic diterpene extracted from rosemary. Reports have shown that CA possesses anticancer activity. However, whether CA inhibits esophageal squamous cell carcinoma, an aggressive type of esophageal cancer, remains untested. METHODS: The effects of CA on cell survival, migration, and apoptosis were evaluated by a combination of MTT, colony formation assay, flow cytometry, and Transwell assay. The potential signaling pathways involved were investigated via Western blot assay. RESULTS: CA dose-dependently inhibited cell proliferation, apoptosis, migration, and colony formation. Mechanistically, CA arrested the cell cycle at G2/M phase, promoted cell apoptosis, induced DNA damage, and inhibited the MAPK signaling pathways. CONCLUSION: Our results suggest that CA is a potential anticancer drug for esophageal squamous cell carcinoma.

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