Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways

BACKGROUND: Carnosic acid (CA) is a polyphenolic diterpene extracted from rosemary. Reports have shown that CA possesses anticancer activity. However, whether CA inhibits esophageal squamous cell carcinoma, an aggressive type of esophageal cancer, remains untested. METHODS: The effects of CA on cell...

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Detalles Bibliográficos
Autores principales: Jiang, Sicong, Qiu, Yinda, Wang, Zhaozhen, Ji, Yulong, Zhang, Xiaofang, Yan, Xiaosong, Zhan, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610725/
https://www.ncbi.nlm.nih.gov/pubmed/34824582
http://dx.doi.org/10.1155/2021/4451533
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author Jiang, Sicong
Qiu, Yinda
Wang, Zhaozhen
Ji, Yulong
Zhang, Xiaofang
Yan, Xiaosong
Zhan, Zhiqiang
author_facet Jiang, Sicong
Qiu, Yinda
Wang, Zhaozhen
Ji, Yulong
Zhang, Xiaofang
Yan, Xiaosong
Zhan, Zhiqiang
author_sort Jiang, Sicong
collection PubMed
description BACKGROUND: Carnosic acid (CA) is a polyphenolic diterpene extracted from rosemary. Reports have shown that CA possesses anticancer activity. However, whether CA inhibits esophageal squamous cell carcinoma, an aggressive type of esophageal cancer, remains untested. METHODS: The effects of CA on cell survival, migration, and apoptosis were evaluated by a combination of MTT, colony formation assay, flow cytometry, and Transwell assay. The potential signaling pathways involved were investigated via Western blot assay. RESULTS: CA dose-dependently inhibited cell proliferation, apoptosis, migration, and colony formation. Mechanistically, CA arrested the cell cycle at G2/M phase, promoted cell apoptosis, induced DNA damage, and inhibited the MAPK signaling pathways. CONCLUSION: Our results suggest that CA is a potential anticancer drug for esophageal squamous cell carcinoma.
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spelling pubmed-86107252021-11-24 Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways Jiang, Sicong Qiu, Yinda Wang, Zhaozhen Ji, Yulong Zhang, Xiaofang Yan, Xiaosong Zhan, Zhiqiang J Oncol Research Article BACKGROUND: Carnosic acid (CA) is a polyphenolic diterpene extracted from rosemary. Reports have shown that CA possesses anticancer activity. However, whether CA inhibits esophageal squamous cell carcinoma, an aggressive type of esophageal cancer, remains untested. METHODS: The effects of CA on cell survival, migration, and apoptosis were evaluated by a combination of MTT, colony formation assay, flow cytometry, and Transwell assay. The potential signaling pathways involved were investigated via Western blot assay. RESULTS: CA dose-dependently inhibited cell proliferation, apoptosis, migration, and colony formation. Mechanistically, CA arrested the cell cycle at G2/M phase, promoted cell apoptosis, induced DNA damage, and inhibited the MAPK signaling pathways. CONCLUSION: Our results suggest that CA is a potential anticancer drug for esophageal squamous cell carcinoma. Hindawi 2021-11-16 /pmc/articles/PMC8610725/ /pubmed/34824582 http://dx.doi.org/10.1155/2021/4451533 Text en Copyright © 2021 Sicong Jiang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jiang, Sicong
Qiu, Yinda
Wang, Zhaozhen
Ji, Yulong
Zhang, Xiaofang
Yan, Xiaosong
Zhan, Zhiqiang
Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
title Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
title_full Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
title_fullStr Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
title_full_unstemmed Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
title_short Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
title_sort carnosic acid induces antiproliferation and anti-metastatic property of esophageal cancer cells via mapk signaling pathways
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610725/
https://www.ncbi.nlm.nih.gov/pubmed/34824582
http://dx.doi.org/10.1155/2021/4451533
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