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Bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis
Bacteria of the human intestinal microflora have a dual role. They promote digestion and are part of a defense mechanism against pathogens. These bacteria could become potential pathogens under certain circumstances. The term “bacterial translocation” describes the passage of bacteria of the gastroi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611185/ https://www.ncbi.nlm.nih.gov/pubmed/34877025 http://dx.doi.org/10.4291/wjgp.v12.i6.106 |
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author | Doudakmanis, Christos Bouliaris, Konstantinos Kolla, Christina Efthimiou, Matthaios Koukoulis, Georgios D |
author_facet | Doudakmanis, Christos Bouliaris, Konstantinos Kolla, Christina Efthimiou, Matthaios Koukoulis, Georgios D |
author_sort | Doudakmanis, Christos |
collection | PubMed |
description | Bacteria of the human intestinal microflora have a dual role. They promote digestion and are part of a defense mechanism against pathogens. These bacteria could become potential pathogens under certain circumstances. The term “bacterial translocation” describes the passage of bacteria of the gastrointestinal tract through the intestinal mucosa barrier to mesenteric lymph nodes and other organs. In some cases, the passage of bacteria and endotoxins could result in blood stream infections and in multiple organ failure. Open elective abdominal surgery more frequently results in malfunction of the intestinal barrier and subsequent bacterial translocation and blood stream infections than laparoscopic surgery. Postoperative sepsis is a common finding in patients who have undergone non-elective abdominal surgeries, including trauma patients treated with laparotomy. Postoperative sepsis is an emerging issue, as it changes the treatment plan in surgical patients and prolongs hospital stay. The association between bacterial translocation and postoperative sepsis could provide novel treatment options. |
format | Online Article Text |
id | pubmed-8611185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-86111852021-12-06 Bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis Doudakmanis, Christos Bouliaris, Konstantinos Kolla, Christina Efthimiou, Matthaios Koukoulis, Georgios D World J Gastrointest Pathophysiol Editorial Bacteria of the human intestinal microflora have a dual role. They promote digestion and are part of a defense mechanism against pathogens. These bacteria could become potential pathogens under certain circumstances. The term “bacterial translocation” describes the passage of bacteria of the gastrointestinal tract through the intestinal mucosa barrier to mesenteric lymph nodes and other organs. In some cases, the passage of bacteria and endotoxins could result in blood stream infections and in multiple organ failure. Open elective abdominal surgery more frequently results in malfunction of the intestinal barrier and subsequent bacterial translocation and blood stream infections than laparoscopic surgery. Postoperative sepsis is a common finding in patients who have undergone non-elective abdominal surgeries, including trauma patients treated with laparotomy. Postoperative sepsis is an emerging issue, as it changes the treatment plan in surgical patients and prolongs hospital stay. The association between bacterial translocation and postoperative sepsis could provide novel treatment options. Baishideng Publishing Group Inc 2021-11-22 2021-11-22 /pmc/articles/PMC8611185/ /pubmed/34877025 http://dx.doi.org/10.4291/wjgp.v12.i6.106 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Editorial Doudakmanis, Christos Bouliaris, Konstantinos Kolla, Christina Efthimiou, Matthaios Koukoulis, Georgios D Bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis |
title | Bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis |
title_full | Bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis |
title_fullStr | Bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis |
title_full_unstemmed | Bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis |
title_short | Bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis |
title_sort | bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611185/ https://www.ncbi.nlm.nih.gov/pubmed/34877025 http://dx.doi.org/10.4291/wjgp.v12.i6.106 |
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