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Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions

Bacteria are known to communicate with each other and regulate their activities in social networks by secreting and sensing signaling molecules called autoinducers, a process known as quorum sensing (QS). This is a growing area of research in which we are expanding our understanding of how bacteria...

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Autores principales: Coquant, Garance, Aguanno, Doriane, Pham, Sandrine, Grellier, Nathan, Thenet, Sophie, Carrière, Véronique, Grill, Jean-Pierre, Seksik, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611211/
https://www.ncbi.nlm.nih.gov/pubmed/34876787
http://dx.doi.org/10.3748/wjg.v27.i42.7247
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author Coquant, Garance
Aguanno, Doriane
Pham, Sandrine
Grellier, Nathan
Thenet, Sophie
Carrière, Véronique
Grill, Jean-Pierre
Seksik, Philippe
author_facet Coquant, Garance
Aguanno, Doriane
Pham, Sandrine
Grellier, Nathan
Thenet, Sophie
Carrière, Véronique
Grill, Jean-Pierre
Seksik, Philippe
author_sort Coquant, Garance
collection PubMed
description Bacteria are known to communicate with each other and regulate their activities in social networks by secreting and sensing signaling molecules called autoinducers, a process known as quorum sensing (QS). This is a growing area of research in which we are expanding our understanding of how bacteria collectively modify their behavior but are also involved in the crosstalk between the host and gut microbiome. This is particularly relevant in the case of pathologies associated with dysbiosis or disorders of the intestinal ecosystem. This review will examine the different QS systems and the evidence for their presence in the intestinal ecosystem. We will also provide clues on the role of QS molecules that may exert, directly or indirectly through their bacterial gossip, an influence on intestinal epithelial barrier function, intestinal inflammation, and intestinal carcinogenesis. This review aims to provide evidence on the role of QS molecules in gut physiology and the potential shared by this new player. Better understanding the impact of intestinal bacterial social networks and ultimately developing new therapeutic strategies to control intestinal disorders remains a challenge that needs to be addressed in the future.
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spelling pubmed-86112112021-12-06 Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions Coquant, Garance Aguanno, Doriane Pham, Sandrine Grellier, Nathan Thenet, Sophie Carrière, Véronique Grill, Jean-Pierre Seksik, Philippe World J Gastroenterol Review Bacteria are known to communicate with each other and regulate their activities in social networks by secreting and sensing signaling molecules called autoinducers, a process known as quorum sensing (QS). This is a growing area of research in which we are expanding our understanding of how bacteria collectively modify their behavior but are also involved in the crosstalk between the host and gut microbiome. This is particularly relevant in the case of pathologies associated with dysbiosis or disorders of the intestinal ecosystem. This review will examine the different QS systems and the evidence for their presence in the intestinal ecosystem. We will also provide clues on the role of QS molecules that may exert, directly or indirectly through their bacterial gossip, an influence on intestinal epithelial barrier function, intestinal inflammation, and intestinal carcinogenesis. This review aims to provide evidence on the role of QS molecules in gut physiology and the potential shared by this new player. Better understanding the impact of intestinal bacterial social networks and ultimately developing new therapeutic strategies to control intestinal disorders remains a challenge that needs to be addressed in the future. Baishideng Publishing Group Inc 2021-11-14 2021-11-14 /pmc/articles/PMC8611211/ /pubmed/34876787 http://dx.doi.org/10.3748/wjg.v27.i42.7247 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Coquant, Garance
Aguanno, Doriane
Pham, Sandrine
Grellier, Nathan
Thenet, Sophie
Carrière, Véronique
Grill, Jean-Pierre
Seksik, Philippe
Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions
title Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions
title_full Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions
title_fullStr Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions
title_full_unstemmed Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions
title_short Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions
title_sort gossip in the gut: quorum sensing, a new player in the host-microbiota interactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611211/
https://www.ncbi.nlm.nih.gov/pubmed/34876787
http://dx.doi.org/10.3748/wjg.v27.i42.7247
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