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Engineering of Ocriplasmin Variants by Bioinformatics Methods for the Reduction of Proteolytic and Autolytic Activities

BACKGROUND: Ocriplasmin has been developed for the induction of posterior vitreous detachment in patients with vitreomacular adhesion. At physiological pH, ocriplasmin is susceptible to autolytic and proteolytic degradation, limiting its activity duration. These undesirable properties of ocriplasmin...

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Detalles Bibliográficos
Autores principales:	Baghban, Roghayyeh, Farajnia, Safar, Ghasemi, Younes, Mortazavi, Mojtaba, Ghasemali, Samaneh, Zakariazadeh, Mostafa, Zarghami, Nosratollah, Samadi, Nasser
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shiraz University of Medical Sciences 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611222/ https://www.ncbi.nlm.nih.gov/pubmed/34840386 http://dx.doi.org/10.30476/ijms.2020.86984.1705

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