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An efficient synthesis of furan-3(2H)-imine scaffold from alkynones
A novel efficient method to generate spiro furan-3(2H)-imine derivatives is established by the reaction between the α,β-unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to pr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611349/ https://www.ncbi.nlm.nih.gov/pubmed/34849246 http://dx.doi.org/10.1098/rsos.211145 |
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author | Rasras, Anas J. Shehadi, Ihsan A. Younes, Eyad A. Jaradat, Da'san M. M. AlQawasmeh, Raed A. |
author_facet | Rasras, Anas J. Shehadi, Ihsan A. Younes, Eyad A. Jaradat, Da'san M. M. AlQawasmeh, Raed A. |
author_sort | Rasras, Anas J. |
collection | PubMed |
description | A novel efficient method to generate spiro furan-3(2H)-imine derivatives is established by the reaction between the α,β-unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to produce the furan-3(2H)-imine. All the synthesized compounds are characterized using nuclear magnetic resonance and high-resolution mass spectrometry (HRMS). |
format | Online Article Text |
id | pubmed-8611349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-86113492021-11-29 An efficient synthesis of furan-3(2H)-imine scaffold from alkynones Rasras, Anas J. Shehadi, Ihsan A. Younes, Eyad A. Jaradat, Da'san M. M. AlQawasmeh, Raed A. R Soc Open Sci Chemistry A novel efficient method to generate spiro furan-3(2H)-imine derivatives is established by the reaction between the α,β-unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to produce the furan-3(2H)-imine. All the synthesized compounds are characterized using nuclear magnetic resonance and high-resolution mass spectrometry (HRMS). The Royal Society 2021-11-24 /pmc/articles/PMC8611349/ /pubmed/34849246 http://dx.doi.org/10.1098/rsos.211145 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Chemistry Rasras, Anas J. Shehadi, Ihsan A. Younes, Eyad A. Jaradat, Da'san M. M. AlQawasmeh, Raed A. An efficient synthesis of furan-3(2H)-imine scaffold from alkynones |
title | An efficient synthesis of furan-3(2H)-imine scaffold from alkynones |
title_full | An efficient synthesis of furan-3(2H)-imine scaffold from alkynones |
title_fullStr | An efficient synthesis of furan-3(2H)-imine scaffold from alkynones |
title_full_unstemmed | An efficient synthesis of furan-3(2H)-imine scaffold from alkynones |
title_short | An efficient synthesis of furan-3(2H)-imine scaffold from alkynones |
title_sort | efficient synthesis of furan-3(2h)-imine scaffold from alkynones |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611349/ https://www.ncbi.nlm.nih.gov/pubmed/34849246 http://dx.doi.org/10.1098/rsos.211145 |
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