Cargando…

An efficient synthesis of furan-3(2H)-imine scaffold from alkynones

A novel efficient method to generate spiro furan-3(2H)-imine derivatives is established by the reaction between the α,β-unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Rasras, Anas J., Shehadi, Ihsan A., Younes, Eyad A., Jaradat, Da'san M. M., AlQawasmeh, Raed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611349/
https://www.ncbi.nlm.nih.gov/pubmed/34849246
http://dx.doi.org/10.1098/rsos.211145
_version_ 1784603276457541632
author Rasras, Anas J.
Shehadi, Ihsan A.
Younes, Eyad A.
Jaradat, Da'san M. M.
AlQawasmeh, Raed A.
author_facet Rasras, Anas J.
Shehadi, Ihsan A.
Younes, Eyad A.
Jaradat, Da'san M. M.
AlQawasmeh, Raed A.
author_sort Rasras, Anas J.
collection PubMed
description A novel efficient method to generate spiro furan-3(2H)-imine derivatives is established by the reaction between the α,β-unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to produce the furan-3(2H)-imine. All the synthesized compounds are characterized using nuclear magnetic resonance and high-resolution mass spectrometry (HRMS).
format Online
Article
Text
id pubmed-8611349
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-86113492021-11-29 An efficient synthesis of furan-3(2H)-imine scaffold from alkynones Rasras, Anas J. Shehadi, Ihsan A. Younes, Eyad A. Jaradat, Da'san M. M. AlQawasmeh, Raed A. R Soc Open Sci Chemistry A novel efficient method to generate spiro furan-3(2H)-imine derivatives is established by the reaction between the α,β-unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to produce the furan-3(2H)-imine. All the synthesized compounds are characterized using nuclear magnetic resonance and high-resolution mass spectrometry (HRMS). The Royal Society 2021-11-24 /pmc/articles/PMC8611349/ /pubmed/34849246 http://dx.doi.org/10.1098/rsos.211145 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Chemistry
Rasras, Anas J.
Shehadi, Ihsan A.
Younes, Eyad A.
Jaradat, Da'san M. M.
AlQawasmeh, Raed A.
An efficient synthesis of furan-3(2H)-imine scaffold from alkynones
title An efficient synthesis of furan-3(2H)-imine scaffold from alkynones
title_full An efficient synthesis of furan-3(2H)-imine scaffold from alkynones
title_fullStr An efficient synthesis of furan-3(2H)-imine scaffold from alkynones
title_full_unstemmed An efficient synthesis of furan-3(2H)-imine scaffold from alkynones
title_short An efficient synthesis of furan-3(2H)-imine scaffold from alkynones
title_sort efficient synthesis of furan-3(2h)-imine scaffold from alkynones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611349/
https://www.ncbi.nlm.nih.gov/pubmed/34849246
http://dx.doi.org/10.1098/rsos.211145
work_keys_str_mv AT rasrasanasj anefficientsynthesisoffuran32himinescaffoldfromalkynones
AT shehadiihsana anefficientsynthesisoffuran32himinescaffoldfromalkynones
AT youneseyada anefficientsynthesisoffuran32himinescaffoldfromalkynones
AT jaradatdasanmm anefficientsynthesisoffuran32himinescaffoldfromalkynones
AT alqawasmehraeda anefficientsynthesisoffuran32himinescaffoldfromalkynones
AT rasrasanasj efficientsynthesisoffuran32himinescaffoldfromalkynones
AT shehadiihsana efficientsynthesisoffuran32himinescaffoldfromalkynones
AT youneseyada efficientsynthesisoffuran32himinescaffoldfromalkynones
AT jaradatdasanmm efficientsynthesisoffuran32himinescaffoldfromalkynones
AT alqawasmehraeda efficientsynthesisoffuran32himinescaffoldfromalkynones