Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with multiple spike mutations enable increased transmission and antibody resistance. We combined cryo–electron microscopy (cryo-EM), binding, and computational analyses to study variant spikes, including one that was involved in t...

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Detalles Bibliográficos
Autores principales: Gobeil, Sophie M.-C., Janowska, Katarzyna, McDowell, Shana, Mansouri, Katayoun, Parks, Robert, Stalls, Victoria, Kopp, Megan F., Manne, Kartik, Li, Dapeng, Wiehe, Kevin, Saunders, Kevin O., Edwards, Robert J., Korber, Bette, Haynes, Barton F., Henderson, Rory, Acharya, Priyamvada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611377/
https://www.ncbi.nlm.nih.gov/pubmed/34168071
http://dx.doi.org/10.1126/science.abi6226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611377/
https://www.ncbi.nlm.nih.gov/pubmed/34168071
http://dx.doi.org/10.1126/science.abi6226

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