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Pan-cancer landscape of CD274 (PD-L1) rearrangements in 283,050 patient samples, its correlation with PD-L1 protein expression, and immunotherapy response

BACKGROUND: Immune checkpoint inhibitors (ICIs) benefit patients with multiple cancer types, however, additional predictive biomarkers of response are needed. CD274 (programmed cell death ligand-1, PD-L1) gene rearrangements are positively associated with PD-L1 expression and may confer benefit to I...

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Detalles Bibliográficos
Autores principales:	Kelly, Andrew D, Murugesan, Karthikeyan, Kuang, Zheng, Montesion, Meagan, Ross, Jeffrey S, Albacker, Lee A, Huang, Richard S P, Lin, Douglas I, Demirci, Umut, Creeden, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Immunotherapy Biomarkers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611421/ https://www.ncbi.nlm.nih.gov/pubmed/34815356 http://dx.doi.org/10.1136/jitc-2021-003550

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