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Does lineage plasticity enable escape from CAR-T cell therapy? Lessons from MLL-r leukemia

The clinical success of engineered, CD19-directed chimeric antigen receptor (CAR) T cells in relapsed, refractory B-cell acute lymphoblastic leukemia (B-ALL) has generated great enthusiasm for the use of CAR T cells in patients with cytogenetics that portend a poor prognosis with conventional cytoto...

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Detalles Bibliográficos
Autores principales:	Liao, Wenjuan, Kohler, M. Eric, Fry, Terry, Ernst, Patricia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611617/ https://www.ncbi.nlm.nih.gov/pubmed/34298117 http://dx.doi.org/10.1016/j.exphem.2021.07.002

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