A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients

Immune checkpoint inhibitor (ICI) therapy continues to revolutionize melanoma treatment, but only a subset of patients respond. Major efforts are underway to develop minimally invasive predictive assays of ICI response. Using single-cell transcriptomics, we discovered a unique CD8 T cell blood/tumor...

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Detalles Bibliográficos
Autores principales: Li, Chuan, Phoon, Yee Peng, Karlinsey, Keaton, Tian, Ye F., Thapaliya, Samjhana, Thongkum, Angkana, Qu, Lili, Matz, Alyssa Joyce, Cameron, Mark, Cameron, Cheryl, Menoret, Antoine, Funchain, Pauline, Song, Jung-Min, Diaz-Montero, C. Marcela, Tamilselvan, Banumathi, Golden, Jackelyn B., Cartwright, Michael, Rodriguez, Annabelle, Bonin, Christopher, Vella, Anthony, Zhou, Beiyan, Gastman, Brian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611729/
https://www.ncbi.nlm.nih.gov/pubmed/34807232
http://dx.doi.org/10.1084/jem.20202084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611729/
https://www.ncbi.nlm.nih.gov/pubmed/34807232
http://dx.doi.org/10.1084/jem.20202084

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