Induced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway

Proposed model for the anti‐apoptotic effects of induced neural stem/progenitor cell (iNPC)‐derived extracellular vesicles (EVs). iNPC release EVs that are abundantly loaded with growth factor‐related proteins. These growth factor‐enriched EVs enhance the phosphorylation of extracellular signal‐regu...

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Detalles Bibliográficos
Autores principales: Ma, Yizhao, Xu, Xiaonan, Li, Chunhong, Wang, Yi, Zhu, Jie, Xia, Xiaohuan, Zheng, Jialin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611769/
https://www.ncbi.nlm.nih.gov/pubmed/34643059
http://dx.doi.org/10.1111/cns.13744
Descripción
Sumario:Proposed model for the anti‐apoptotic effects of induced neural stem/progenitor cell (iNPC)‐derived extracellular vesicles (EVs). iNPC release EVs that are abundantly loaded with growth factor‐related proteins. These growth factor‐enriched EVs enhance the phosphorylation of extracellular signal‐regulated kinase (ERK), but not AKt. The EV‐induced activation of ERK pathway then inhibit the apoptosis of NPCs in various pathological conditions including oxidative stress and starvation. [Image: see text]

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