Induced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway

Proposed model for the anti‐apoptotic effects of induced neural stem/progenitor cell (iNPC)‐derived extracellular vesicles (EVs). iNPC release EVs that are abundantly loaded with growth factor‐related proteins. These growth factor‐enriched EVs enhance the phosphorylation of extracellular signal‐regu...

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Detalles Bibliográficos
Autores principales: Ma, Yizhao, Xu, Xiaonan, Li, Chunhong, Wang, Yi, Zhu, Jie, Xia, Xiaohuan, Zheng, Jialin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611769/
https://www.ncbi.nlm.nih.gov/pubmed/34643059
http://dx.doi.org/10.1111/cns.13744
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author Ma, Yizhao
Xu, Xiaonan
Li, Chunhong
Wang, Yi
Zhu, Jie
Xia, Xiaohuan
Zheng, Jialin C.
author_facet Ma, Yizhao
Xu, Xiaonan
Li, Chunhong
Wang, Yi
Zhu, Jie
Xia, Xiaohuan
Zheng, Jialin C.
author_sort Ma, Yizhao
collection PubMed
description Proposed model for the anti‐apoptotic effects of induced neural stem/progenitor cell (iNPC)‐derived extracellular vesicles (EVs). iNPC release EVs that are abundantly loaded with growth factor‐related proteins. These growth factor‐enriched EVs enhance the phosphorylation of extracellular signal‐regulated kinase (ERK), but not AKt. The EV‐induced activation of ERK pathway then inhibit the apoptosis of NPCs in various pathological conditions including oxidative stress and starvation. [Image: see text]
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spelling pubmed-86117692021-11-30 Induced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway Ma, Yizhao Xu, Xiaonan Li, Chunhong Wang, Yi Zhu, Jie Xia, Xiaohuan Zheng, Jialin C. CNS Neurosci Ther Letters to the Editor Proposed model for the anti‐apoptotic effects of induced neural stem/progenitor cell (iNPC)‐derived extracellular vesicles (EVs). iNPC release EVs that are abundantly loaded with growth factor‐related proteins. These growth factor‐enriched EVs enhance the phosphorylation of extracellular signal‐regulated kinase (ERK), but not AKt. The EV‐induced activation of ERK pathway then inhibit the apoptosis of NPCs in various pathological conditions including oxidative stress and starvation. [Image: see text] John Wiley and Sons Inc. 2021-10-13 /pmc/articles/PMC8611769/ /pubmed/34643059 http://dx.doi.org/10.1111/cns.13744 Text en © 2021 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letters to the Editor
Ma, Yizhao
Xu, Xiaonan
Li, Chunhong
Wang, Yi
Zhu, Jie
Xia, Xiaohuan
Zheng, Jialin C.
Induced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway
title Induced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway
title_full Induced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway
title_fullStr Induced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway
title_full_unstemmed Induced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway
title_short Induced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway
title_sort induced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway
topic Letters to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611769/
https://www.ncbi.nlm.nih.gov/pubmed/34643059
http://dx.doi.org/10.1111/cns.13744
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