Men with COVID-19 die. Women survive

The severity and mortality rate of COVID-19 differ between the sexes. Several biopsychosocial determinants may account for the better outcomes in women. The notion that sex steroid hormones account for the gender disparity is reasonable but not proven; the same is true of the role of menopause as a...

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Autores principales: Ferretti, Virginia V., Klersy, Catherine, Bruno, Raffaele, Cutti, Sara, Nappi, Rossella E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611817/
https://www.ncbi.nlm.nih.gov/pubmed/35241235
http://dx.doi.org/10.1016/j.maturitas.2021.11.014
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author Ferretti, Virginia V.
Klersy, Catherine
Bruno, Raffaele
Cutti, Sara
Nappi, Rossella E.
author_facet Ferretti, Virginia V.
Klersy, Catherine
Bruno, Raffaele
Cutti, Sara
Nappi, Rossella E.
author_sort Ferretti, Virginia V.
collection PubMed
description The severity and mortality rate of COVID-19 differ between the sexes. Several biopsychosocial determinants may account for the better outcomes in women. The notion that sex steroid hormones account for the gender disparity is reasonable but not proven; the same is true of the role of menopause as a risk factor. A retrospective analysis of patients (=1764) hospitalized in Italy showed a higher mortality (HR 1.58, 95%CI 1.30–1.91, adjusted for age and multi-comorbidities) in males only after the age of 65 (the rate is twice as high in the 65–79-year age group and 1.5-fold higher in those aged over 80). The higher mortality of men is mostly evident among those aged over 65 years, long after the average age of menopause.
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spelling pubmed-86118172021-11-24 Men with COVID-19 die. Women survive Ferretti, Virginia V. Klersy, Catherine Bruno, Raffaele Cutti, Sara Nappi, Rossella E. Maturitas Article The severity and mortality rate of COVID-19 differ between the sexes. Several biopsychosocial determinants may account for the better outcomes in women. The notion that sex steroid hormones account for the gender disparity is reasonable but not proven; the same is true of the role of menopause as a risk factor. A retrospective analysis of patients (=1764) hospitalized in Italy showed a higher mortality (HR 1.58, 95%CI 1.30–1.91, adjusted for age and multi-comorbidities) in males only after the age of 65 (the rate is twice as high in the 65–79-year age group and 1.5-fold higher in those aged over 80). The higher mortality of men is mostly evident among those aged over 65 years, long after the average age of menopause. Elsevier B.V. 2022-04 2021-11-24 /pmc/articles/PMC8611817/ /pubmed/35241235 http://dx.doi.org/10.1016/j.maturitas.2021.11.014 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ferretti, Virginia V.
Klersy, Catherine
Bruno, Raffaele
Cutti, Sara
Nappi, Rossella E.
Men with COVID-19 die. Women survive
title Men with COVID-19 die. Women survive
title_full Men with COVID-19 die. Women survive
title_fullStr Men with COVID-19 die. Women survive
title_full_unstemmed Men with COVID-19 die. Women survive
title_short Men with COVID-19 die. Women survive
title_sort men with covid-19 die. women survive
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611817/
https://www.ncbi.nlm.nih.gov/pubmed/35241235
http://dx.doi.org/10.1016/j.maturitas.2021.11.014
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AT nappirossellae menwithcovid19diewomensurvive

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