Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds

Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83). The same was the case when cerebellar extracts from a case of multiple system atrophy with ty...

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Detalles Bibliográficos
Autores principales: Macdonald, Jennifer A., Chen, John L., Masuda-Suzukake, Masami, Schweighauser, Manuel, Jaunmuktane, Zane, Warner, Thomas, Holton, Janice L., Grossman, Annabelle, Berks, Richard, Lavenir, Isabelle, Goedert, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611835/
https://www.ncbi.nlm.nih.gov/pubmed/34819144
http://dx.doi.org/10.1186/s40478-021-01291-7

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