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Prognostic Value of E2F Transcription Factor Expression in Pancreatic Adenocarcinoma

BACKGROUND: Pancreatic adenocarcinoma (PAAD) is one of the deadliest types of cancer. In the early stages, patients often have atypical symptoms, making diagnosis difficult. The prognosis of diagnosed patients is very poor and treating PAAD is challenging. Therefore, determining reliable risk factor...

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Autores principales: Luo, Lin, Zhang, Gerui, Wu, Taihua, Wu, Guangzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611937/
https://www.ncbi.nlm.nih.gov/pubmed/34799547
http://dx.doi.org/10.12659/MSM.933443
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author Luo, Lin
Zhang, Gerui
Wu, Taihua
Wu, Guangzhen
author_facet Luo, Lin
Zhang, Gerui
Wu, Taihua
Wu, Guangzhen
author_sort Luo, Lin
collection PubMed
description BACKGROUND: Pancreatic adenocarcinoma (PAAD) is one of the deadliest types of cancer. In the early stages, patients often have atypical symptoms, making diagnosis difficult. The prognosis of diagnosed patients is very poor and treating PAAD is challenging. Therefore, determining reliable risk factors related to PAAD development is critical for improving patient prognosis. E2F family transcription factors (TFs) are essential regulators of DNA synthesis and cell cycle progression in eukaryotic cells, and they have been identified as prognostic biomarkers associated with multiple cancer types. However, further research is necessary to establish the prognostic relevance of these TFs in PAAD patients. MATERIAL/METHODS: We assessed PAAD patient transcriptional and outcome data using the TIMER, ONCOMINE, STRING, GEPIA, cBioPortal, Kaplan-Meier Plotter, GSCALite, and starBase databases. RESULTS: PAAD tumor tissues exhibited increased expression of E2F1/3/5/7/8 relative to that in normal tissues, while the expression of E2F2/3/6/8 was associated with a more advanced tumor stage. Survival analyses indicated that PAAD patients expressing higher levels of E2F1/2/3/7/8 exhibited shorter overall survival (OS) and disease-free survival (DFS) than patients expressing lower levels of these TFs. In addition, E2F4 and E2F6 overexpression was associated with poorer DFS and OS, respectively. We also found that the expression of E2Fs was significantly correlated with immune infiltrates, including CD8+ T cells, CD4+ T cells, B cells, dendritic cells, neutrophils, and macrophages. CONCLUSIONS: Our study may provide new insights into the optimal choice of immunotherapy and promising novel targets for therapeutic intervention in PAAD patients.
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spelling pubmed-86119372021-12-07 Prognostic Value of E2F Transcription Factor Expression in Pancreatic Adenocarcinoma Luo, Lin Zhang, Gerui Wu, Taihua Wu, Guangzhen Med Sci Monit Database Analysis BACKGROUND: Pancreatic adenocarcinoma (PAAD) is one of the deadliest types of cancer. In the early stages, patients often have atypical symptoms, making diagnosis difficult. The prognosis of diagnosed patients is very poor and treating PAAD is challenging. Therefore, determining reliable risk factors related to PAAD development is critical for improving patient prognosis. E2F family transcription factors (TFs) are essential regulators of DNA synthesis and cell cycle progression in eukaryotic cells, and they have been identified as prognostic biomarkers associated with multiple cancer types. However, further research is necessary to establish the prognostic relevance of these TFs in PAAD patients. MATERIAL/METHODS: We assessed PAAD patient transcriptional and outcome data using the TIMER, ONCOMINE, STRING, GEPIA, cBioPortal, Kaplan-Meier Plotter, GSCALite, and starBase databases. RESULTS: PAAD tumor tissues exhibited increased expression of E2F1/3/5/7/8 relative to that in normal tissues, while the expression of E2F2/3/6/8 was associated with a more advanced tumor stage. Survival analyses indicated that PAAD patients expressing higher levels of E2F1/2/3/7/8 exhibited shorter overall survival (OS) and disease-free survival (DFS) than patients expressing lower levels of these TFs. In addition, E2F4 and E2F6 overexpression was associated with poorer DFS and OS, respectively. We also found that the expression of E2Fs was significantly correlated with immune infiltrates, including CD8+ T cells, CD4+ T cells, B cells, dendritic cells, neutrophils, and macrophages. CONCLUSIONS: Our study may provide new insights into the optimal choice of immunotherapy and promising novel targets for therapeutic intervention in PAAD patients. International Scientific Literature, Inc. 2021-11-20 /pmc/articles/PMC8611937/ /pubmed/34799547 http://dx.doi.org/10.12659/MSM.933443 Text en © Med Sci Monit, 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Database Analysis
Luo, Lin
Zhang, Gerui
Wu, Taihua
Wu, Guangzhen
Prognostic Value of E2F Transcription Factor Expression in Pancreatic Adenocarcinoma
title Prognostic Value of E2F Transcription Factor Expression in Pancreatic Adenocarcinoma
title_full Prognostic Value of E2F Transcription Factor Expression in Pancreatic Adenocarcinoma
title_fullStr Prognostic Value of E2F Transcription Factor Expression in Pancreatic Adenocarcinoma
title_full_unstemmed Prognostic Value of E2F Transcription Factor Expression in Pancreatic Adenocarcinoma
title_short Prognostic Value of E2F Transcription Factor Expression in Pancreatic Adenocarcinoma
title_sort prognostic value of e2f transcription factor expression in pancreatic adenocarcinoma
topic Database Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611937/
https://www.ncbi.nlm.nih.gov/pubmed/34799547
http://dx.doi.org/10.12659/MSM.933443
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