Broad-Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524)

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The necessity for intravenous administration of remdesivir confines its utility for treatment of coronavirus disease 2019 (COVID-19) to hospitalized patients. We evaluated the broad-spectrum antiviral activity of ODBG-P-RVn, an orally available, lipid-modified monophosphate prodrug of the remdesivir...

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Detalles Bibliográficos
Autores principales: Lo, Michael K., Shrivastava-Ranjan, Punya, Chatterjee, Payel, Flint, Mike, Beadle, James R., Valiaeva, Nadejda, Murphy, Joyce, Schooley, Robert T., Hostetler, Karl Y., Montgomery, Joel M., Spiropoulou, Christina F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612139/
https://www.ncbi.nlm.nih.gov/pubmed/34817209
http://dx.doi.org/10.1128/Spectrum.01537-21
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