Prospective Activity of PLG0206, an Engineered Antimicrobial Peptide, on Chronic Periprosthetic Joint Infection Total Knee Arthroplasty Components Ex Vivo: The Knee Explant Analysis (KnEA) Study

PLG0206 is an engineered antimicrobial peptide that has completed phase 1 clinical studies. A prospective study was completed on explanted implants from chronic periprosthetic joint infections (n = 17). At a concentration of 1 mg/mL for 15 min, there was a mean 4-log(10) reduction (range, 1 to 7) in...

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Detalles Bibliográficos
Autores principales: Huang, David, Parker, Dana M., Mandell, Jonathan B., Brothers, Kimberly M., Gish, Charles G., Koch, John A., Pachuda, Nicholas, Dobbins, Despina, Steckbeck, Jonathan, Urish, Kenneth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612143/
https://www.ncbi.nlm.nih.gov/pubmed/34817227
http://dx.doi.org/10.1128/Spectrum.01879-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612143/
https://www.ncbi.nlm.nih.gov/pubmed/34817227
http://dx.doi.org/10.1128/Spectrum.01879-21

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