A Rapid Drug Resistance Genotyping Workflow for Mycobacterium tuberculosis, Using Targeted Isothermal Amplification and Nanopore Sequencing

Phenotypic drug susceptibility testing (DST) for tuberculosis (TB) requires weeks to yield results. Although molecular tests rapidly detect drug resistance-associated mutations (DRMs), they are not scalable to cover the full genome and the many DRMs that can predict resistance. Whole-genome sequenci...

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Detalles Bibliográficos
Autores principales: Gliddon, Harriet D., Frampton, Dan, Munsamy, Vanisha, Heaney, Jude, Pataillot-Meakin, Thomas, Nastouli, Eleni, Pym, Alexander S., Steyn, Adrie J. C., Pillay, Deenan, McKendry, Rachel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612157/
https://www.ncbi.nlm.nih.gov/pubmed/34817282
http://dx.doi.org/10.1128/Spectrum.00610-21

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