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The cell-surface 5′-nucleotidase CD73 defines a functional T memory cell subset that declines with age

Memory T cells exhibit considerable diversity that determines their ability to be protective. Here, we examine whether changes in T cell heterogeneity contribute to the age-associated failure of immune memory. By screening for age-dependent T cell-surface markers, we identify CD4 and CD8 memory T ce...

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Detalles Bibliográficos
Autores principales: Fang, Fengqin, Cao, Wenqiang, Zhu, Weikang, Lam, Nora, Li, Lingjie, Gaddam, Sadhana, Wang, Yong, Kim, Chulwoo, Lambert, Simon, Zhang, Huimin, Hu, Bin, Farber, Donna L., Weyand, Cornelia M., Goronzy, Jörg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612175/
https://www.ncbi.nlm.nih.gov/pubmed/34758299
http://dx.doi.org/10.1016/j.celrep.2021.109981
Descripción
Sumario:Memory T cells exhibit considerable diversity that determines their ability to be protective. Here, we examine whether changes in T cell heterogeneity contribute to the age-associated failure of immune memory. By screening for age-dependent T cell-surface markers, we identify CD4 and CD8 memory T cell subsets that are unrelated to previously defined subsets of central and effector memory cells. Memory T cells expressing the ecto-5ʹ-nucleotidase CD73 constitute a functionally distinct subset of memory T cells that declines with age. They resemble long-lived, polyfunctional memory cells but are also poised to display effector functions and to develop into cells resembling tissue-resident memory T cells (T(RMs)). Upstream regulators of differential chromatin accessibility and transcriptomes include transcription factors that facilitate CD73 expression and regulate TRM differentiation. CD73 is not just a surrogate marker of these regulatory networks but is directly involved in T cell survival.