Cargando…

Single-Domain Antibody Nuclear Imaging Allows Noninvasive Quantification of LAG-3 Expression by Tumor-Infiltrating Leukocytes and Predicts Response of Immune Checkpoint Blockade

Recent advances in the field of immune-oncology led to the discovery of next-generation immune checkpoints (ICPs). Lymphocyte activation gene-3 (LAG-3), being the most widely studied among them, is being explored as a target for the treatment of cancer patients. Several antagonistic anti-LAG-3 antib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lecocq, Quentin, Awad, Robin Maximilian, De Vlaeminck, Yannick, de Mey, Wout, Ertveldt, Thomas, Goyvaerts, Cleo, Raes, Geert, Thielemans, Kris, Keyaerts, Marleen, Devoogdt, Nick, Breckpot, Karine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society of Nuclear Medicine 2021
Materias:	Featured Basic Science Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612328/ https://www.ncbi.nlm.nih.gov/pubmed/33712537 http://dx.doi.org/10.2967/jnumed.120.258871

Ejemplares similares

Noninvasive Imaging of the Immune Checkpoint LAG-3 Using Nanobodies, from Development to Pre-Clinical Use
por: Lecocq, Quentin, et al.
Publicado: (2019)

Theranostics in immuno-oncology using nanobody derivatives
por: Lecocq, Quentin, et al.
Publicado: (2019)

Targeted Radionuclide Therapy with Low and High-Dose Lutetium-177–Labeled Single Domain Antibodies Induces Distinct Immune Signatures in a Mouse Melanoma Model
por: Ertveldt, Thomas, et al.
Publicado: (2022)

Formatting and gene-based delivery of a human PD-L1 single domain antibody for immune checkpoint blockade
por: Awad, Robin Maximilian, et al.
Publicado: (2021)

Evaluation of single domain antibodies as nuclear tracers for imaging of the immune checkpoint receptor human lymphocyte activation gene-3 in cancer
por: Lecocq, Q., et al.
Publicado: (2021)

The Next-Generation Immune Checkpoint LAG-3 and Its Therapeutic Potential in Oncology: Third Time’s a Charm
por: Lecocq, Quentin, et al.
Publicado: (2020)

Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy
por: Broos, Katrijn, et al.
Publicado: (2018)

In vitro modelling of local gene therapy with IL-15/IL-15Rα and a PD-L1 antagonist in melanoma reveals an interplay between NK cells and CD4(+) T cells
por: Awad, Robin Maximilian, et al.
Publicado: (2023)

Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT
por: Zeven, Katty, et al.
Publicado: (2023)

Single Domain Antibody-Mediated Blockade of Programmed Death-Ligand 1 on Dendritic Cells Enhances CD8 T-cell Activation and Cytokine Production
por: Broos, Katrijn, et al.
Publicado: (2019)

TNF-α-Secreting Lung Tumor-Infiltrated Monocytes Play a Pivotal Role During Anti-PD-L1 Immunotherapy
por: De Ridder, Kirsten, et al.
Publicado: (2022)

Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression
por: Awad, Robin Maximilian, et al.
Publicado: (2018)

Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8(+) T cell and iNKT cell activating mRNA vaccine
por: Ertveldt, Thomas, et al.
Publicado: (2023)

Cancer-Associated Myeloid Regulatory Cells
por: De Vlaeminck, Yannick, et al.
Publicado: (2016)

Non-invasive assessment of murine PD-L1 levels in syngeneic tumor models by nuclear imaging with nanobody tracers
por: Broos, Katrijn, et al.
Publicado: (2017)

Site-Specific Radiolabeling of a Human PD-L1 Nanobody via Maleimide–Cysteine Chemistry
por: Chigoho, Dora Mugoli, et al.
Publicado: (2021)

Evaluating a Single Domain Antibody Targeting Human PD-L1 as a Nuclear Imaging and Therapeutic Agent
por: Broos, Katrijn, et al.
Publicado: (2019)

RNA in Cancer Immunotherapy: Unlocking the Potential of the Immune System
por: De Mey, Wout, et al.
Publicado: (2022)

Immunogenicity of targeted lentivectors
por: Goyvaerts, Cleo, et al.
Publicado: (2014)

Anti-Human PD-L1 Nanobody for Immuno-PET Imaging: Validation of a Conjugation Strategy for Clinical Translation
por: Bridoux, Jessica, et al.
Publicado: (2020)

Neo-Antigen mRNA Vaccines
por: Esprit, Arthur, et al.
Publicado: (2020)

Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines
por: Goyvaerts, Cleo, et al.
Publicado: (2015)

The Journey of in vivo Virus Engineered Dendritic Cells From Bench to Bedside: A Bumpy Road
por: Goyvaerts, Cleo, et al.
Publicado: (2018)

Targeting Neuropilin-1 with Nanobodies Reduces Colorectal Carcinoma Development
por: De Vlaeminck, Yannick, et al.
Publicado: (2020)

Perforin and Granzyme B Expressed by Murine Myeloid-Derived Suppressor Cells: A Study on Their Role in Outgrowth of Cancer Cells
por: Dufait, Inès, et al.
Publicado: (2019)

Phase I Study of [(68)Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I)
por: Gondry, Odrade, et al.
Publicado: (2023)

Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon
por: Broos, Katrijn, et al.
Publicado: (2016)

Targeting the tumor microenvironment to enhance antitumor immune responses
por: Van der Jeught, Kevin, et al.
Publicado: (2014)

Inhibiting Histone and DNA Methylation Improves Cancer Vaccination in an Experimental Model of Melanoma
por: De Beck, Lien, et al.
Publicado: (2022)

An mRNA mix redirects dendritic cells towards an antiviral program, inducing anticancer cytotoxic stem cell and central memory CD8(+) T cells
por: de Mey, Wout, et al.
Publicado: (2023)

Immunomodulation of the Tumor Microenvironment: Turn Foe Into Friend
por: Locy, Hanne, et al.
Publicado: (2018)

Preclinical Targeted α- and β(−)-Radionuclide Therapy in HER2-Positive Brain Metastasis Using Camelid Single-Domain Antibodies
por: Puttemans, Janik, et al.
Publicado: (2020)

The role of SMAC mimetics in regulation of tumor cell death and immunity
por: Emeagi, Perpetua U., et al.
Publicado: (2012)

A workflow to design new directed domestication programs to move forward current and future insect production
por: Lecocq, Thomas, et al.
Publicado: (2021)

Development of the Nanobody display technology to target lentiviral vectors to antigen-presenting cells
por: Goyvaerts, C, et al.
Publicado: (2012)

A synthetic DNA template for fast manufacturing of versatile single epitope mRNA
por: de Mey, Wout, et al.
Publicado: (2022)

CS1-specific single-domain antibodies labeled with Actinium-225 prolong survival and increase CD8+ T cells and PD-L1 expression in Multiple Myeloma
por: De Veirman, Kim, et al.
Publicado: (2021)

mRNA: From a chemical blueprint for protein production to an off-the-shelf therapeutic
por: Van Lint, Sandra, et al.
Publicado: (2013)

Immunogenicity Risk Profile of Nanobodies
por: Ackaert, Chloé, et al.
Publicado: (2021)

Worth living or worth dying? The views of the general public about allowing disabled children to die
por: Brick, Claudia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_g0tl5thlq0osaqme26tnpg7ttj