Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines

Asymmetric hydrogenation of unsaturated morpholines has been developed by using a bisphosphine-rhodium catalyst bearing a large bite angle. With this approach, a variety of 2-substituted chiral morpholines could be obtained in quantitative yields and with excellent enantioselectivities (up to 99% ee...

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Detalles Bibliográficos
Autores principales: Li, Mingxu, Zhang, Jian, Zou, Yashi, Zhou, Fengfan, Zhang, Zhenfeng, Zhang, Wanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612400/
https://www.ncbi.nlm.nih.gov/pubmed/34909146
http://dx.doi.org/10.1039/d1sc04288b
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author Li, Mingxu
Zhang, Jian
Zou, Yashi
Zhou, Fengfan
Zhang, Zhenfeng
Zhang, Wanbin
author_facet Li, Mingxu
Zhang, Jian
Zou, Yashi
Zhou, Fengfan
Zhang, Zhenfeng
Zhang, Wanbin
author_sort Li, Mingxu
collection PubMed
description Asymmetric hydrogenation of unsaturated morpholines has been developed by using a bisphosphine-rhodium catalyst bearing a large bite angle. With this approach, a variety of 2-substituted chiral morpholines could be obtained in quantitative yields and with excellent enantioselectivities (up to 99% ee). The hydrogenated products could be transformed into key intermediates for bioactive compounds.
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spelling pubmed-86124002021-12-13 Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines Li, Mingxu Zhang, Jian Zou, Yashi Zhou, Fengfan Zhang, Zhenfeng Zhang, Wanbin Chem Sci Chemistry Asymmetric hydrogenation of unsaturated morpholines has been developed by using a bisphosphine-rhodium catalyst bearing a large bite angle. With this approach, a variety of 2-substituted chiral morpholines could be obtained in quantitative yields and with excellent enantioselectivities (up to 99% ee). The hydrogenated products could be transformed into key intermediates for bioactive compounds. The Royal Society of Chemistry 2021-10-28 /pmc/articles/PMC8612400/ /pubmed/34909146 http://dx.doi.org/10.1039/d1sc04288b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Li, Mingxu
Zhang, Jian
Zou, Yashi
Zhou, Fengfan
Zhang, Zhenfeng
Zhang, Wanbin
Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines
title Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines
title_full Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines
title_fullStr Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines
title_full_unstemmed Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines
title_short Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines
title_sort asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612400/
https://www.ncbi.nlm.nih.gov/pubmed/34909146
http://dx.doi.org/10.1039/d1sc04288b
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AT zouyashi asymmetrichydrogenationforthesynthesisof2substitutedchiralmorpholines
AT zhoufengfan asymmetrichydrogenationforthesynthesisof2substitutedchiralmorpholines
AT zhangzhenfeng asymmetrichydrogenationforthesynthesisof2substitutedchiralmorpholines
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