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Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines

Asymmetric hydrogenation of unsaturated morpholines has been developed by using a bisphosphine-rhodium catalyst bearing a large bite angle. With this approach, a variety of 2-substituted chiral morpholines could be obtained in quantitative yields and with excellent enantioselectivities (up to 99% ee...

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Detalles Bibliográficos
Autores principales:	Li, Mingxu, Zhang, Jian, Zou, Yashi, Zhou, Fengfan, Zhang, Zhenfeng, Zhang, Wanbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612400/ https://www.ncbi.nlm.nih.gov/pubmed/34909146 http://dx.doi.org/10.1039/d1sc04288b

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