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SARS-CoV-2 infection in children with rheumatic disease: Experience of a tertiary referral center
OBJECTIVES: In this study, we present our clinical severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) experience in patients with childhood rheumatic disease during novel coronavirus-2019 (COVID-19) pandemic. PATIENTS AND METHODS: A total of 87 patients (50 males, 37 females; median age: 1...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Turkish League Against Rheumatism
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612496/ https://www.ncbi.nlm.nih.gov/pubmed/34870170 http://dx.doi.org/10.46497/ArchRheumatol.2021.8603 |
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author | Sözeri, Betül Demir, Ferhat Kalın, Sevinç Hasbal Akkuş, Canan Salı, Enes Çakır, Deniz |
author_facet | Sözeri, Betül Demir, Ferhat Kalın, Sevinç Hasbal Akkuş, Canan Salı, Enes Çakır, Deniz |
author_sort | Sözeri, Betül |
collection | PubMed |
description | OBJECTIVES: In this study, we present our clinical severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) experience in patients with childhood rheumatic disease during novel coronavirus-2019 (COVID-19) pandemic. PATIENTS AND METHODS: A total of 87 patients (50 males, 37 females; median age: 12 years; range, 6.6 to 16 years) suspected of having COVID-19 at our pediatric rheumatology clinic between March 11th and October 15th 2020 were retrospectively analyzed. Demographic and clinical features, treatments, laboratory results, imaging findings, and clinical outcomes of the patients diagnosed with COVID-19 and/or multisystem inflammatory syndrome in children (MIS-C) were retrieved from the medical records. The diagnosis of SARS-CoV-2 infection was made based on the reverse transcriptase-polymerase chain reaction test. RESULTS: The most common rheumatic diseases were juvenile idiopathic arthritis and familial Mediterranean fever (35.6% and 34.5%, respectively). Twenty-six of these patients were treated with biological disease-modifying anti-rheumatic drugs. SARS-CoV-2 infection was tested as positive in 84 (96.5%) patients. Also, 51 (58.6%) patients had an epidemiological contact to a person with COVID-19. Eighteen patients met the clinical criteria and diagnosed with MIS-C. The COVID-19 outbreak also caused exacerbation of systemic disease in 56 children due to medication cessation, postponed drug switch, or recurrent viral infection. CONCLUSION: Children with rheumatic disease do not appear to present a higher risk of severe COVID-19. The immunosuppressive treatments can be adjusted in case of infection; otherwise, it is not recommended to interrupt the treatments. Physicians should be cautious about the hyperinflammatory syndrome associated with COVID-19 in rheumatic children, which may be severe in this group of patients and may be confused with primary diseases. |
format | Online Article Text |
id | pubmed-8612496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Turkish League Against Rheumatism |
record_format | MEDLINE/PubMed |
spelling | pubmed-86124962021-12-03 SARS-CoV-2 infection in children with rheumatic disease: Experience of a tertiary referral center Sözeri, Betül Demir, Ferhat Kalın, Sevinç Hasbal Akkuş, Canan Salı, Enes Çakır, Deniz Arch Rheumatol Original Article OBJECTIVES: In this study, we present our clinical severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) experience in patients with childhood rheumatic disease during novel coronavirus-2019 (COVID-19) pandemic. PATIENTS AND METHODS: A total of 87 patients (50 males, 37 females; median age: 12 years; range, 6.6 to 16 years) suspected of having COVID-19 at our pediatric rheumatology clinic between March 11th and October 15th 2020 were retrospectively analyzed. Demographic and clinical features, treatments, laboratory results, imaging findings, and clinical outcomes of the patients diagnosed with COVID-19 and/or multisystem inflammatory syndrome in children (MIS-C) were retrieved from the medical records. The diagnosis of SARS-CoV-2 infection was made based on the reverse transcriptase-polymerase chain reaction test. RESULTS: The most common rheumatic diseases were juvenile idiopathic arthritis and familial Mediterranean fever (35.6% and 34.5%, respectively). Twenty-six of these patients were treated with biological disease-modifying anti-rheumatic drugs. SARS-CoV-2 infection was tested as positive in 84 (96.5%) patients. Also, 51 (58.6%) patients had an epidemiological contact to a person with COVID-19. Eighteen patients met the clinical criteria and diagnosed with MIS-C. The COVID-19 outbreak also caused exacerbation of systemic disease in 56 children due to medication cessation, postponed drug switch, or recurrent viral infection. CONCLUSION: Children with rheumatic disease do not appear to present a higher risk of severe COVID-19. The immunosuppressive treatments can be adjusted in case of infection; otherwise, it is not recommended to interrupt the treatments. Physicians should be cautious about the hyperinflammatory syndrome associated with COVID-19 in rheumatic children, which may be severe in this group of patients and may be confused with primary diseases. Turkish League Against Rheumatism 2021-02-09 /pmc/articles/PMC8612496/ /pubmed/34870170 http://dx.doi.org/10.46497/ArchRheumatol.2021.8603 Text en Copyright © 2021, Turkish League Against Rheumatism https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Article Sözeri, Betül Demir, Ferhat Kalın, Sevinç Hasbal Akkuş, Canan Salı, Enes Çakır, Deniz SARS-CoV-2 infection in children with rheumatic disease: Experience of a tertiary referral center |
title | SARS-CoV-2 infection in children with rheumatic disease: Experience of a tertiary referral center |
title_full | SARS-CoV-2 infection in children with rheumatic disease: Experience of a tertiary referral center |
title_fullStr | SARS-CoV-2 infection in children with rheumatic disease: Experience of a tertiary referral center |
title_full_unstemmed | SARS-CoV-2 infection in children with rheumatic disease: Experience of a tertiary referral center |
title_short | SARS-CoV-2 infection in children with rheumatic disease: Experience of a tertiary referral center |
title_sort | sars-cov-2 infection in children with rheumatic disease: experience of a tertiary referral center |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612496/ https://www.ncbi.nlm.nih.gov/pubmed/34870170 http://dx.doi.org/10.46497/ArchRheumatol.2021.8603 |
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