A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function

Schizophrenia is a polygenetic disorder whose clinical onset is often associated with behavioral stress. Here, we present a model of disease pathogenesis that builds on our observation that the synaptic immediate early gene NPTX2 is reduced in cerebrospinal fluid of individuals with recent onset sch...

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Detalles Bibliográficos
Autores principales: Xiao, Mei-Fang, Roh, Seung-Eon, Zhou, Jiechao, Chien, Chun-Che, Lucey, Brendan P., Craig, Michael T., Hayes, Lindsay N., Coughlin, Jennifer M., Leweke, F. Markus, Jia, Min, Xu, Desheng, Zhou, Weiqiang, Conover Talbot, C., Arnold, Don B., Staley, Melissa, Jiang, Cindy, Reti, Irving M., Sawa, Akira, Pelkey, Kenneth A., McBain, Chris J., Savonenko, Alena, Worley, Paul F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612534/
https://www.ncbi.nlm.nih.gov/pubmed/34818031
http://dx.doi.org/10.1126/sciadv.abf6935

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