It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling

Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediat...

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Detalles Bibliográficos
Autores principales: Carvalho, Ana Luisa, Fernandes, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612543/
https://www.ncbi.nlm.nih.gov/pubmed/34818347
http://dx.doi.org/10.1371/journal.pbio.3001448
Descripción
Sumario:Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediate synaptic scaling.

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