It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling

Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediat...

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Detalles Bibliográficos
Autores principales: Carvalho, Ana Luisa, Fernandes, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612543/
https://www.ncbi.nlm.nih.gov/pubmed/34818347
http://dx.doi.org/10.1371/journal.pbio.3001448
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author Carvalho, Ana Luisa
Fernandes, Dominique
author_facet Carvalho, Ana Luisa
Fernandes, Dominique
author_sort Carvalho, Ana Luisa
collection PubMed
description Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediate synaptic scaling.
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spelling pubmed-86125432021-11-25 It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling Carvalho, Ana Luisa Fernandes, Dominique PLoS Biol Primer Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediate synaptic scaling. Public Library of Science 2021-11-24 /pmc/articles/PMC8612543/ /pubmed/34818347 http://dx.doi.org/10.1371/journal.pbio.3001448 Text en © 2021 Carvalho, Fernandes https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Primer
Carvalho, Ana Luisa
Fernandes, Dominique
It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
title It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
title_full It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
title_fullStr It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
title_full_unstemmed It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
title_short It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
title_sort it takes two to tango: concerted protein translation and degradation necessary for synaptic scaling
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612543/
https://www.ncbi.nlm.nih.gov/pubmed/34818347
http://dx.doi.org/10.1371/journal.pbio.3001448
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