Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies

The prion protein (PrP(C)) is a central player in neurodegenerative diseases, such as prion diseases or Alzheimer’s disease. In contrast to disease-promoting cell surface PrP(C), extracellular fragments act neuroprotective by blocking neurotoxic disease-associated protein conformers. Fittingly, PrP(...

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Detalles Bibliográficos
Autores principales: Linsenmeier, Luise, Mohammadi, Behnam, Shafiq, Mohsin, Frontzek, Karl, Bär, Julia, Shrivastava, Amulya N., Damme, Markus, Song, Feizhi, Schwarz, Alexander, Da Vela, Stefano, Massignan, Tania, Jung, Sebastian, Correia, Angela, Schmitz, Matthias, Puig, Berta, Hornemann, Simone, Zerr, Inga, Tatzelt, Jörg, Biasini, Emiliano, Saftig, Paul, Schweizer, Michaela, Svergun, Dmitri, Amin, Ladan, Mazzola, Federica, Varani, Luca, Thapa, Simrika, Gilch, Sabine, Schätzl, Hermann, Harris, David A., Triller, Antoine, Mikhaylova, Marina, Aguzzi, Adriano, Altmeppen, Hermann C., Glatzel, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612689/
https://www.ncbi.nlm.nih.gov/pubmed/34818048
http://dx.doi.org/10.1126/sciadv.abj1826

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