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Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines
Many vaccine candidates with promising results in preclinical testing fail in human trials. New complex human tissue models have the potential to improve the predictability of vaccine safety and efficacy in human clinical trials.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612770/ https://www.ncbi.nlm.nih.gov/pubmed/34767552 http://dx.doi.org/10.1371/journal.pbio.3001462 |
| _version_ | 1784603512503533568 |
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| author | Kessie, David Komla Rudel, Thomas |
| author_facet | Kessie, David Komla Rudel, Thomas |
| author_sort | Kessie, David Komla |
| collection | PubMed |
| description | Many vaccine candidates with promising results in preclinical testing fail in human trials. New complex human tissue models have the potential to improve the predictability of vaccine safety and efficacy in human clinical trials. |
| format | Online Article Text |
| id | pubmed-8612770 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-86127702021-11-25 Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines Kessie, David Komla Rudel, Thomas PLoS Biol Perspective Many vaccine candidates with promising results in preclinical testing fail in human trials. New complex human tissue models have the potential to improve the predictability of vaccine safety and efficacy in human clinical trials. Public Library of Science 2021-11-12 /pmc/articles/PMC8612770/ /pubmed/34767552 http://dx.doi.org/10.1371/journal.pbio.3001462 Text en © 2021 Kessie, Rudel https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| spellingShingle | Perspective Kessie, David Komla Rudel, Thomas Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines |
| title | Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines |
| title_full | Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines |
| title_fullStr | Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines |
| title_full_unstemmed | Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines |
| title_short | Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines |
| title_sort | advanced human mucosal tissue models are needed to improve preclinical testing of vaccines |
| topic | Perspective |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612770/ https://www.ncbi.nlm.nih.gov/pubmed/34767552 http://dx.doi.org/10.1371/journal.pbio.3001462 |
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