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Exposures of Phenylacetic Acid and Phenylacetylglutamine Across Different Subpopulations and Correlation with Adverse Events

BACKGROUND: Elevated plasma ammonia is central to the pathogenesis of hepatic encephalopathy. Sodium phenylacetate or glycerol phenylbutyrate is approved for urea cycle disorders, but limited clinical data are available for hepatic encephalopathy. Phenylacetic acid (PAA) plasma exposure has been rep...

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Detalles Bibliográficos
Autores principales:	Wang, Xiaofeng, Tseng, Jack, Mak, Carmen, Poola, Nagaraju, Vilchez, Regis A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613126/ https://www.ncbi.nlm.nih.gov/pubmed/34125423 http://dx.doi.org/10.1007/s40262-021-01047-5

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