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Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia

Clinical and prognostic differences between symptomatic and asymptomatic older patients with COVID-19 are of great interest since frail patients often show atypical presentation of illness. Lung Ultrasound (LUS) has been proven to be a reliable tool for detecting early-phase COVID-19 pneumonic alter...

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Autores principales: Okoye, Chukwuma, Calsolaro, Valeria, Fabbri, Alessandra, Franchi, Riccardo, Antognoli, Rachele, Zisca, Ludovica, Bianchi, Camilla, Calabrese, Alessia Maria, Rogani, Sara, Monzani, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613196/
https://www.ncbi.nlm.nih.gov/pubmed/34819555
http://dx.doi.org/10.1038/s41598-021-02275-2
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author Okoye, Chukwuma
Calsolaro, Valeria
Fabbri, Alessandra
Franchi, Riccardo
Antognoli, Rachele
Zisca, Ludovica
Bianchi, Camilla
Calabrese, Alessia Maria
Rogani, Sara
Monzani, Fabio
author_facet Okoye, Chukwuma
Calsolaro, Valeria
Fabbri, Alessandra
Franchi, Riccardo
Antognoli, Rachele
Zisca, Ludovica
Bianchi, Camilla
Calabrese, Alessia Maria
Rogani, Sara
Monzani, Fabio
author_sort Okoye, Chukwuma
collection PubMed
description Clinical and prognostic differences between symptomatic and asymptomatic older patients with COVID-19 are of great interest since frail patients often show atypical presentation of illness. Lung Ultrasound (LUS) has been proven to be a reliable tool for detecting early-phase COVID-19 pneumonic alterations. The current prospective bicentric study aimed to compare LUS score and 3-month overall mortality between asymptomatic and symptomatic older patients with COVID-19, according to frailty status. Patients were stratified according to LUS score tertiles and Clinical Frailty Scale categories. Survival rate was assessed by telephone interviews 3 months after discharge. 64 symptomatic (24 women, aged 80.0 ± 10.8 years) and 46 asymptomatic (31 women, aged 84.3 ± 8.8 years) were consecutively enrolled. LUS score resulted an independent predictor of 3-month mortality [OR 2.27 (CI95% 1.09–4.8), p = 0.03], and the highest mortality rate was observed in symptomatic and asymptomatic pre-frail and frail patients (70.6% and 66.7%, respectively) with greater LUS abnormalities (3rd tertile). In conclusion, LUS identified an acute interstitial lung involvement in most of the older asymptomatic patients. Mortality rate progressively increased according to clinical frailty and LUS score degree, resulting a reliable prognostic tool in both symptomatic and asymptomatic patients.
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spelling pubmed-86131962021-11-26 Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia Okoye, Chukwuma Calsolaro, Valeria Fabbri, Alessandra Franchi, Riccardo Antognoli, Rachele Zisca, Ludovica Bianchi, Camilla Calabrese, Alessia Maria Rogani, Sara Monzani, Fabio Sci Rep Article Clinical and prognostic differences between symptomatic and asymptomatic older patients with COVID-19 are of great interest since frail patients often show atypical presentation of illness. Lung Ultrasound (LUS) has been proven to be a reliable tool for detecting early-phase COVID-19 pneumonic alterations. The current prospective bicentric study aimed to compare LUS score and 3-month overall mortality between asymptomatic and symptomatic older patients with COVID-19, according to frailty status. Patients were stratified according to LUS score tertiles and Clinical Frailty Scale categories. Survival rate was assessed by telephone interviews 3 months after discharge. 64 symptomatic (24 women, aged 80.0 ± 10.8 years) and 46 asymptomatic (31 women, aged 84.3 ± 8.8 years) were consecutively enrolled. LUS score resulted an independent predictor of 3-month mortality [OR 2.27 (CI95% 1.09–4.8), p = 0.03], and the highest mortality rate was observed in symptomatic and asymptomatic pre-frail and frail patients (70.6% and 66.7%, respectively) with greater LUS abnormalities (3rd tertile). In conclusion, LUS identified an acute interstitial lung involvement in most of the older asymptomatic patients. Mortality rate progressively increased according to clinical frailty and LUS score degree, resulting a reliable prognostic tool in both symptomatic and asymptomatic patients. Nature Publishing Group UK 2021-11-24 /pmc/articles/PMC8613196/ /pubmed/34819555 http://dx.doi.org/10.1038/s41598-021-02275-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Okoye, Chukwuma
Calsolaro, Valeria
Fabbri, Alessandra
Franchi, Riccardo
Antognoli, Rachele
Zisca, Ludovica
Bianchi, Camilla
Calabrese, Alessia Maria
Rogani, Sara
Monzani, Fabio
Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia
title Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia
title_full Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia
title_fullStr Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia
title_full_unstemmed Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia
title_short Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia
title_sort usefulness of lung ultrasound for selecting asymptomatic older patients with covid 19 pneumonia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613196/
https://www.ncbi.nlm.nih.gov/pubmed/34819555
http://dx.doi.org/10.1038/s41598-021-02275-2
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