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Blood phenylalanine reduction reverses gene expression changes observed in a mouse model of phenylketonuria

Phenylketonuria (PKU) is a genetic deficiency of phenylalanine hydroxylase (PAH) in liver resulting in blood phenylalanine (Phe) elevation and neurotoxicity. A pegylated phenylalanine ammonia lyase (PEG-PAL) metabolizing Phe into cinnamic acid was recently approved as treatment for PKU patients. A p...

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Detalles Bibliográficos
Autores principales:	Manek, Rachna, Zhang, Yao V., Berthelette, Patricia, Hossain, Mahmud, Cornell, Cathleen S., Gans, Joseph, Anarat-Cappillino, Gulbenk, Geller, Sarah, Jackson, Robert, Yu, Dan, Singh, Kuldeep, Ryan, Sue, Bangari, Dinesh S., Xu, Ethan Y., Kyostio-Moore, Sirkka R. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613214/ https://www.ncbi.nlm.nih.gov/pubmed/34819582 http://dx.doi.org/10.1038/s41598-021-02267-2

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