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Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress
The balances between NSCs growth and differentiation, and between glial and neuronal differentiation play a key role in brain regeneration after any pathological conditions. It is well known that the nervous tissue shows a poor recovery after injury due to the factors present in the wounded microenv...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613233/ https://www.ncbi.nlm.nih.gov/pubmed/34819604 http://dx.doi.org/10.1038/s41598-021-02361-5 |
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author | Magaquian, Dario Delgado Ocaña, Susana Perez, Consuelo Banchio, Claudia |
author_facet | Magaquian, Dario Delgado Ocaña, Susana Perez, Consuelo Banchio, Claudia |
author_sort | Magaquian, Dario |
collection | PubMed |
description | The balances between NSCs growth and differentiation, and between glial and neuronal differentiation play a key role in brain regeneration after any pathological conditions. It is well known that the nervous tissue shows a poor recovery after injury due to the factors present in the wounded microenvironment, particularly inflammatory factors, that prevent neuronal differentiation. Thus, it is essential to generate a favourable condition for NSCs and conduct them to differentiate towards functional neurons. Here, we show that neuroinflammation has no effect on NSCs proliferation but induces an aberrant neuronal differentiation that gives rise to dystrophic, non-functional neurons. This is perhaps the initial step of brain failure associated to many neurological disorders. Interestingly, we demonstrate that phosphatidylcholine (PtdCho)-enriched media enhances neuronal differentiation even under inflammatory stress by modifying the commitment of post-mitotic cells. The pro-neurogenic effect of PtdCho increases the population of healthy normal neurons. In addition, we provide evidences that this phospholipid ameliorates the damage of neurons and, in consequence, modulates neuronal plasticity. These results contribute to our understanding of NSCs behaviour under inflammatory conditions, opening up new venues to improve neurogenic capacity in the brain. |
format | Online Article Text |
id | pubmed-8613233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-86132332021-11-26 Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress Magaquian, Dario Delgado Ocaña, Susana Perez, Consuelo Banchio, Claudia Sci Rep Article The balances between NSCs growth and differentiation, and between glial and neuronal differentiation play a key role in brain regeneration after any pathological conditions. It is well known that the nervous tissue shows a poor recovery after injury due to the factors present in the wounded microenvironment, particularly inflammatory factors, that prevent neuronal differentiation. Thus, it is essential to generate a favourable condition for NSCs and conduct them to differentiate towards functional neurons. Here, we show that neuroinflammation has no effect on NSCs proliferation but induces an aberrant neuronal differentiation that gives rise to dystrophic, non-functional neurons. This is perhaps the initial step of brain failure associated to many neurological disorders. Interestingly, we demonstrate that phosphatidylcholine (PtdCho)-enriched media enhances neuronal differentiation even under inflammatory stress by modifying the commitment of post-mitotic cells. The pro-neurogenic effect of PtdCho increases the population of healthy normal neurons. In addition, we provide evidences that this phospholipid ameliorates the damage of neurons and, in consequence, modulates neuronal plasticity. These results contribute to our understanding of NSCs behaviour under inflammatory conditions, opening up new venues to improve neurogenic capacity in the brain. Nature Publishing Group UK 2021-11-24 /pmc/articles/PMC8613233/ /pubmed/34819604 http://dx.doi.org/10.1038/s41598-021-02361-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Magaquian, Dario Delgado Ocaña, Susana Perez, Consuelo Banchio, Claudia Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress |
title | Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress |
title_full | Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress |
title_fullStr | Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress |
title_full_unstemmed | Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress |
title_short | Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress |
title_sort | phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613233/ https://www.ncbi.nlm.nih.gov/pubmed/34819604 http://dx.doi.org/10.1038/s41598-021-02361-5 |
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