ATR inhibition enables complete tumour regression in ALK-driven NB mouse models

High-risk neuroblastoma (NB) often involves MYCN amplification as well as mutations in ALK. Currently, high-risk NB presents significant clinical challenges, and additional therapeutic options are needed. Oncogenes like MYCN and ALK result in increased replication stress in cancer cells, offering th...

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Detalles Bibliográficos
Autores principales: Szydzik, Joanna, Lind, Dan E., Arefin, Badrul, Kurhe, Yeshwant, Umapathy, Ganesh, Siaw, Joachim Tetteh, Claeys, Arne, Gabre, Jonatan L., Van den Eynden, Jimmy, Hallberg, Bengt, Palmer, Ruth H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613282/
https://www.ncbi.nlm.nih.gov/pubmed/34819497
http://dx.doi.org/10.1038/s41467-021-27057-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613282/
https://www.ncbi.nlm.nih.gov/pubmed/34819497
http://dx.doi.org/10.1038/s41467-021-27057-2

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