Treatment of Crohn's Disease and Concomitant Alopecia Areata With Tofacitinib

Alopecia areata (AA) is a type of immune-mediated hair loss and is reported in patients with inflammatory bowel disease. This suggests that there might be a shared molecular pathway in the pathogenesis of AA and inflammatory bowel disease. In addition, tumor necrosis factor-alpha antagonists are als...

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Detalles Bibliográficos
Autores principales: Akiyama, Shintaro, Lin, Austin, Traboulsi, Cindy, Rubin, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613360/
https://www.ncbi.nlm.nih.gov/pubmed/34840997
http://dx.doi.org/10.14309/crj.0000000000000690
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author Akiyama, Shintaro
Lin, Austin
Traboulsi, Cindy
Rubin, David T.
author_facet Akiyama, Shintaro
Lin, Austin
Traboulsi, Cindy
Rubin, David T.
author_sort Akiyama, Shintaro
collection PubMed
description Alopecia areata (AA) is a type of immune-mediated hair loss and is reported in patients with inflammatory bowel disease. This suggests that there might be a shared molecular pathway in the pathogenesis of AA and inflammatory bowel disease. In addition, tumor necrosis factor-alpha antagonists are also rarely associated with new-onset AA. We present a patient with Crohn's disease treated with adalimumab who developed AA that rapidly progressed to alopecia totalis and universalis. We describe the use of tofacitinib, a Janus kinase 1/3 inhibitor, to not only successfully treat the AA but also maintain her Crohn's disease.
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spelling pubmed-86133602021-11-26 Treatment of Crohn's Disease and Concomitant Alopecia Areata With Tofacitinib Akiyama, Shintaro Lin, Austin Traboulsi, Cindy Rubin, David T. ACG Case Rep J Case Report Alopecia areata (AA) is a type of immune-mediated hair loss and is reported in patients with inflammatory bowel disease. This suggests that there might be a shared molecular pathway in the pathogenesis of AA and inflammatory bowel disease. In addition, tumor necrosis factor-alpha antagonists are also rarely associated with new-onset AA. We present a patient with Crohn's disease treated with adalimumab who developed AA that rapidly progressed to alopecia totalis and universalis. We describe the use of tofacitinib, a Janus kinase 1/3 inhibitor, to not only successfully treat the AA but also maintain her Crohn's disease. Wolters Kluwer 2021-11-24 /pmc/articles/PMC8613360/ /pubmed/34840997 http://dx.doi.org/10.14309/crj.0000000000000690 Text en © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Akiyama, Shintaro
Lin, Austin
Traboulsi, Cindy
Rubin, David T.
Treatment of Crohn's Disease and Concomitant Alopecia Areata With Tofacitinib
title Treatment of Crohn's Disease and Concomitant Alopecia Areata With Tofacitinib
title_full Treatment of Crohn's Disease and Concomitant Alopecia Areata With Tofacitinib
title_fullStr Treatment of Crohn's Disease and Concomitant Alopecia Areata With Tofacitinib
title_full_unstemmed Treatment of Crohn's Disease and Concomitant Alopecia Areata With Tofacitinib
title_short Treatment of Crohn's Disease and Concomitant Alopecia Areata With Tofacitinib
title_sort treatment of crohn's disease and concomitant alopecia areata with tofacitinib
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613360/
https://www.ncbi.nlm.nih.gov/pubmed/34840997
http://dx.doi.org/10.14309/crj.0000000000000690
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