FSC231 alleviates paclitaxel‐induced neuralgia by inhibiting the interactions between PICK1 and GluA2 and activates GSK‐3β and ERK1/2

BACKGROUND: FSC231, a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of protein kinase Cα interacting protein 1 (PICK1), has analgesic effects, but the mechanism remains unclear. METHODS: The expression level of PICK1 in dorsal root ganglion (DRG) of rats was changed by vector plasmid, and the effect of PIC...

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Detalles Bibliográficos
Autores principales: Zhang, Xi, Wang, Jiagao, Ran, Ran, Peng, Yuchuan, Xiao, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613442/
https://www.ncbi.nlm.nih.gov/pubmed/34582111
http://dx.doi.org/10.1002/brb3.2380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613442/
https://www.ncbi.nlm.nih.gov/pubmed/34582111
http://dx.doi.org/10.1002/brb3.2380

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