Pathological Complete Response to Neoadjuvant Chemotherapy in a Patient with HER2-Positive Squamous Cell Carcinoma of the Breast

Squamous cell carcinoma (SCC) of the breast is a rare malignancy that usually has a triple-negative phenotype and poor clinical outcomes. Because HER2-positive SCC of the breast is extremely rare, its clinicopathologic features are understudied, and the effects of neoadjuvant chemotherapy including...

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Autores principales: Usui, Yuki, Matsunuma, Ryoichi, Yamaguchi, Kei, Hayami, Ryosuke, Muramatsu, Aya, Suzuki, Makoto, Tsuneizumi, Michiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613576/
https://www.ncbi.nlm.nih.gov/pubmed/34899248
http://dx.doi.org/10.1159/000519746
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author Usui, Yuki
Matsunuma, Ryoichi
Yamaguchi, Kei
Hayami, Ryosuke
Muramatsu, Aya
Suzuki, Makoto
Tsuneizumi, Michiko
author_facet Usui, Yuki
Matsunuma, Ryoichi
Yamaguchi, Kei
Hayami, Ryosuke
Muramatsu, Aya
Suzuki, Makoto
Tsuneizumi, Michiko
author_sort Usui, Yuki
collection PubMed
description Squamous cell carcinoma (SCC) of the breast is a rare malignancy that usually has a triple-negative phenotype and poor clinical outcomes. Because HER2-positive SCC of the breast is extremely rare, its clinicopathologic features are understudied, and the effects of neoadjuvant chemotherapy including anti-HER2-targeted therapy on the tumor are unclear, although treatment resistance was described in some reports. In this study, we reported a case of HER2-positive SCC of the breast in which a pathological complete response to neoadjuvant chemotherapy was observed.
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spelling pubmed-86135762021-12-09 Pathological Complete Response to Neoadjuvant Chemotherapy in a Patient with HER2-Positive Squamous Cell Carcinoma of the Breast Usui, Yuki Matsunuma, Ryoichi Yamaguchi, Kei Hayami, Ryosuke Muramatsu, Aya Suzuki, Makoto Tsuneizumi, Michiko Case Rep Oncol Case Report Squamous cell carcinoma (SCC) of the breast is a rare malignancy that usually has a triple-negative phenotype and poor clinical outcomes. Because HER2-positive SCC of the breast is extremely rare, its clinicopathologic features are understudied, and the effects of neoadjuvant chemotherapy including anti-HER2-targeted therapy on the tumor are unclear, although treatment resistance was described in some reports. In this study, we reported a case of HER2-positive SCC of the breast in which a pathological complete response to neoadjuvant chemotherapy was observed. S. Karger AG 2021-10-22 /pmc/articles/PMC8613576/ /pubmed/34899248 http://dx.doi.org/10.1159/000519746 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Usui, Yuki
Matsunuma, Ryoichi
Yamaguchi, Kei
Hayami, Ryosuke
Muramatsu, Aya
Suzuki, Makoto
Tsuneizumi, Michiko
Pathological Complete Response to Neoadjuvant Chemotherapy in a Patient with HER2-Positive Squamous Cell Carcinoma of the Breast
title Pathological Complete Response to Neoadjuvant Chemotherapy in a Patient with HER2-Positive Squamous Cell Carcinoma of the Breast
title_full Pathological Complete Response to Neoadjuvant Chemotherapy in a Patient with HER2-Positive Squamous Cell Carcinoma of the Breast
title_fullStr Pathological Complete Response to Neoadjuvant Chemotherapy in a Patient with HER2-Positive Squamous Cell Carcinoma of the Breast
title_full_unstemmed Pathological Complete Response to Neoadjuvant Chemotherapy in a Patient with HER2-Positive Squamous Cell Carcinoma of the Breast
title_short Pathological Complete Response to Neoadjuvant Chemotherapy in a Patient with HER2-Positive Squamous Cell Carcinoma of the Breast
title_sort pathological complete response to neoadjuvant chemotherapy in a patient with her2-positive squamous cell carcinoma of the breast
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613576/
https://www.ncbi.nlm.nih.gov/pubmed/34899248
http://dx.doi.org/10.1159/000519746
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